Mycobacterium marinum dermatitis and panniculitis with chronic pleuritis in a captive white whale (Delphinapterus leucas) with aortic rupture

Kathryn E. Bowenkamp, Salvatore Frasca, Andrew Draghi, Gregory J. Tsongalis, Claudia Koerting, Lynn Hinckley, Sylvain De Guise, Richard J. Montali, Caroline E C Goertz, David J. St Aubin, J. Lawrence Dunn

Research output: Contribution to journalArticle

Abstract

A 16-year-old female white whale, Delphinapterus leucas, died after nearly 18 months of chronic lymphopenia and pyogranulomatous dermatitis. Necropsy revealed rupture of the aorta with hemorrhage into the cranial mediastinum and between fascial planes of the ventral neck musculature. Multiple foci of ulcerative dermatitis and panniculitis were present across the thorax and abdomen and surrounded the genital folds. In addition, there was a chronic proliferative pleuritis with over 20 liters of histiocytic exudate in the thoracic cavity. Acid-fast bacteria consistent with Mycobacterium sp. were identified in sections of skin lesions and in cytospins of pleural exudate. Cultures of pleura and 1 skin lesion collected at necropsy yielded sparse growth of an acid-fast bacillus with colony characteristics and morphology consistent with Mycobacterium marinum. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis confirmed the presence of M. marinum DNA in samples of skin. This is the first documented occurrence of mycobacteriosis in a white whale and is a unique presentation of mycobacterial dermatitis and panniculitis with chronic pleuritis in a cetacean. The improved PCR-RFLP protocol utilized in this case unifies techniques from several protocols to differentiate between species of Nocardia and rapidly growing mycobacteria clinically relevant to aquatic animals.

Original languageEnglish (US)
Pages (from-to)524-530
Number of pages7
JournalJournal of Veterinary Diagnostic Investigation
Volume13
Issue number6
StatePublished - 2001
Externally publishedYes

Fingerprint

Beluga Whale
Mycobacterium marinum
Delphinapterus leucas
Panniculitis
Aortic Rupture
Pleurisy
Dermatitis
dermatitis
whales
Mycobacterium
skin lesions
Exudates and Transudates
Restriction Fragment Length Polymorphisms
Skin
necropsy
restriction fragment length polymorphism
polymerase chain reaction
mediastinum
Thoracic Cavity
Nocardia

ASJC Scopus subject areas

  • Microbiology
  • veterinary(all)

Cite this

Bowenkamp, K. E., Frasca, S., Draghi, A., Tsongalis, G. J., Koerting, C., Hinckley, L., ... Dunn, J. L. (2001). Mycobacterium marinum dermatitis and panniculitis with chronic pleuritis in a captive white whale (Delphinapterus leucas) with aortic rupture. Journal of Veterinary Diagnostic Investigation, 13(6), 524-530.

Mycobacterium marinum dermatitis and panniculitis with chronic pleuritis in a captive white whale (Delphinapterus leucas) with aortic rupture. / Bowenkamp, Kathryn E.; Frasca, Salvatore; Draghi, Andrew; Tsongalis, Gregory J.; Koerting, Claudia; Hinckley, Lynn; De Guise, Sylvain; Montali, Richard J.; Goertz, Caroline E C; St Aubin, David J.; Dunn, J. Lawrence.

In: Journal of Veterinary Diagnostic Investigation, Vol. 13, No. 6, 2001, p. 524-530.

Research output: Contribution to journalArticle

Bowenkamp, KE, Frasca, S, Draghi, A, Tsongalis, GJ, Koerting, C, Hinckley, L, De Guise, S, Montali, RJ, Goertz, CEC, St Aubin, DJ & Dunn, JL 2001, 'Mycobacterium marinum dermatitis and panniculitis with chronic pleuritis in a captive white whale (Delphinapterus leucas) with aortic rupture', Journal of Veterinary Diagnostic Investigation, vol. 13, no. 6, pp. 524-530.
Bowenkamp, Kathryn E. ; Frasca, Salvatore ; Draghi, Andrew ; Tsongalis, Gregory J. ; Koerting, Claudia ; Hinckley, Lynn ; De Guise, Sylvain ; Montali, Richard J. ; Goertz, Caroline E C ; St Aubin, David J. ; Dunn, J. Lawrence. / Mycobacterium marinum dermatitis and panniculitis with chronic pleuritis in a captive white whale (Delphinapterus leucas) with aortic rupture. In: Journal of Veterinary Diagnostic Investigation. 2001 ; Vol. 13, No. 6. pp. 524-530.
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