Mycobacterium avium complex (MAC) osteomyelitis and septic arthritis in an immunocompetent host

A. R. Jones, John Bartlett, J. G. McCormack

Research output: Contribution to journalArticle

Abstract

We describe a case of Mycobacterium avium complex (MAC) osteomyelitis and septic arthritis in an immunocompetent man. Infection was derived from a chainsaw injury sustained on the lateral aspect of the ankle 13 years earlier, and had spread through the bone, joint and soft tissue emerging at the medial aspect. This was successfully treated with surgical debridement, drainage, arthrodesis and 18 months of chemotherapy consisting of clarithromycin, rifampicin, ethambutol, and ciprofloxacin with an initial 2 weeks of amikacin. Infections with this organism are generally associated with immunocompromised states, particularly advanced AIDS. However, our patient illustrates that atypical mycobacterial infections must also be considered in immunocompetent patients who have a prolonged clinical course and an appropriate potential source of infection.

Original languageEnglish (US)
Pages (from-to)59-62
Number of pages4
JournalJournal of Infection
Volume30
Issue number1
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Mycobacterium avium Complex
Infectious Arthritis
Osteomyelitis
Infection
Ethambutol
Clarithromycin
Amikacin
Arthrodesis
Debridement
Rifampin
Ciprofloxacin
Ankle
Drainage
Acquired Immunodeficiency Syndrome
Joints
Bone and Bones
Drug Therapy
Wounds and Injuries

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy

Cite this

Mycobacterium avium complex (MAC) osteomyelitis and septic arthritis in an immunocompetent host. / Jones, A. R.; Bartlett, John; McCormack, J. G.

In: Journal of Infection, Vol. 30, No. 1, 1995, p. 59-62.

Research output: Contribution to journalArticle

@article{e6e5f41e25cd4dcab2ced67f1e4a307b,
title = "Mycobacterium avium complex (MAC) osteomyelitis and septic arthritis in an immunocompetent host",
abstract = "We describe a case of Mycobacterium avium complex (MAC) osteomyelitis and septic arthritis in an immunocompetent man. Infection was derived from a chainsaw injury sustained on the lateral aspect of the ankle 13 years earlier, and had spread through the bone, joint and soft tissue emerging at the medial aspect. This was successfully treated with surgical debridement, drainage, arthrodesis and 18 months of chemotherapy consisting of clarithromycin, rifampicin, ethambutol, and ciprofloxacin with an initial 2 weeks of amikacin. Infections with this organism are generally associated with immunocompromised states, particularly advanced AIDS. However, our patient illustrates that atypical mycobacterial infections must also be considered in immunocompetent patients who have a prolonged clinical course and an appropriate potential source of infection.",
author = "Jones, {A. R.} and John Bartlett and McCormack, {J. G.}",
year = "1995",
doi = "10.1016/S0163-4453(95)92925-8",
language = "English (US)",
volume = "30",
pages = "59--62",
journal = "Journal of Infection",
issn = "0163-4453",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Mycobacterium avium complex (MAC) osteomyelitis and septic arthritis in an immunocompetent host

AU - Jones, A. R.

AU - Bartlett, John

AU - McCormack, J. G.

PY - 1995

Y1 - 1995

N2 - We describe a case of Mycobacterium avium complex (MAC) osteomyelitis and septic arthritis in an immunocompetent man. Infection was derived from a chainsaw injury sustained on the lateral aspect of the ankle 13 years earlier, and had spread through the bone, joint and soft tissue emerging at the medial aspect. This was successfully treated with surgical debridement, drainage, arthrodesis and 18 months of chemotherapy consisting of clarithromycin, rifampicin, ethambutol, and ciprofloxacin with an initial 2 weeks of amikacin. Infections with this organism are generally associated with immunocompromised states, particularly advanced AIDS. However, our patient illustrates that atypical mycobacterial infections must also be considered in immunocompetent patients who have a prolonged clinical course and an appropriate potential source of infection.

AB - We describe a case of Mycobacterium avium complex (MAC) osteomyelitis and septic arthritis in an immunocompetent man. Infection was derived from a chainsaw injury sustained on the lateral aspect of the ankle 13 years earlier, and had spread through the bone, joint and soft tissue emerging at the medial aspect. This was successfully treated with surgical debridement, drainage, arthrodesis and 18 months of chemotherapy consisting of clarithromycin, rifampicin, ethambutol, and ciprofloxacin with an initial 2 weeks of amikacin. Infections with this organism are generally associated with immunocompromised states, particularly advanced AIDS. However, our patient illustrates that atypical mycobacterial infections must also be considered in immunocompetent patients who have a prolonged clinical course and an appropriate potential source of infection.

UR - http://www.scopus.com/inward/record.url?scp=0028920737&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028920737&partnerID=8YFLogxK

U2 - 10.1016/S0163-4453(95)92925-8

DO - 10.1016/S0163-4453(95)92925-8

M3 - Article

C2 - 7751669

AN - SCOPUS:0028920737

VL - 30

SP - 59

EP - 62

JO - Journal of Infection

JF - Journal of Infection

SN - 0163-4453

IS - 1

ER -