Myc: Maestro of MicroRNAs

Thi V. Bui, Joshua T. Mendell

Research output: Contribution to journalArticle

Abstract

Hyperactivity of the Myc oncogenic transcription factor dramatically reprograms gene expression to facilitate cellular proliferation and tumorigenesis. To elicit these effects, Myc coordinates the activation and repression of an extensive network of protein-coding genes and, as has recently been appreciated, noncoding RNAs including microRNAs (miRNAs). Consistent with their ability to potently influence cancer phenotypes, the regulation of miRNAs by Myc affects virtually all aspects of the Myc oncogenic program, including proliferation, survival, metabolism, angiogenesis, and metastasis. This review will summarize the current understanding of the mechanisms underlying Myc-dependent transcriptional and posttranscriptional control of miRNAs and the resultant effects on tumorigenesis. As miRNAs are integral nodes in the transcriptional network controlled by Myc, modulating their activity represents a promising new approach for cancer therapy.

Original languageEnglish (US)
Pages (from-to)568-575
Number of pages8
JournalGenes and Cancer
Volume1
Issue number6
DOIs
StatePublished - 2010

Fingerprint

MicroRNAs
Carcinogenesis
Untranslated RNA
Gene Regulatory Networks
Neoplasms
Transcription Factors
Cell Proliferation
Neoplasm Metastasis
Phenotype
Gene Expression
Proteins
Therapeutics

Keywords

  • microRNA
  • Myc
  • Oncogene
  • Tumor suppressor

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

Cite this

Bui, T. V., & Mendell, J. T. (2010). Myc: Maestro of MicroRNAs. Genes and Cancer, 1(6), 568-575. https://doi.org/10.1177/1947601910377491

Myc : Maestro of MicroRNAs. / Bui, Thi V.; Mendell, Joshua T.

In: Genes and Cancer, Vol. 1, No. 6, 2010, p. 568-575.

Research output: Contribution to journalArticle

Bui, TV & Mendell, JT 2010, 'Myc: Maestro of MicroRNAs', Genes and Cancer, vol. 1, no. 6, pp. 568-575. https://doi.org/10.1177/1947601910377491
Bui, Thi V. ; Mendell, Joshua T. / Myc : Maestro of MicroRNAs. In: Genes and Cancer. 2010 ; Vol. 1, No. 6. pp. 568-575.
@article{64ecb9de71b740a5a6d69f2596d27739,
title = "Myc: Maestro of MicroRNAs",
abstract = "Hyperactivity of the Myc oncogenic transcription factor dramatically reprograms gene expression to facilitate cellular proliferation and tumorigenesis. To elicit these effects, Myc coordinates the activation and repression of an extensive network of protein-coding genes and, as has recently been appreciated, noncoding RNAs including microRNAs (miRNAs). Consistent with their ability to potently influence cancer phenotypes, the regulation of miRNAs by Myc affects virtually all aspects of the Myc oncogenic program, including proliferation, survival, metabolism, angiogenesis, and metastasis. This review will summarize the current understanding of the mechanisms underlying Myc-dependent transcriptional and posttranscriptional control of miRNAs and the resultant effects on tumorigenesis. As miRNAs are integral nodes in the transcriptional network controlled by Myc, modulating their activity represents a promising new approach for cancer therapy.",
keywords = "microRNA, Myc, Oncogene, Tumor suppressor",
author = "Bui, {Thi V.} and Mendell, {Joshua T.}",
year = "2010",
doi = "10.1177/1947601910377491",
language = "English (US)",
volume = "1",
pages = "568--575",
journal = "Genes and Cancer",
issn = "1947-6019",
publisher = "SAGE Publications Inc.",
number = "6",

}

TY - JOUR

T1 - Myc

T2 - Maestro of MicroRNAs

AU - Bui, Thi V.

AU - Mendell, Joshua T.

PY - 2010

Y1 - 2010

N2 - Hyperactivity of the Myc oncogenic transcription factor dramatically reprograms gene expression to facilitate cellular proliferation and tumorigenesis. To elicit these effects, Myc coordinates the activation and repression of an extensive network of protein-coding genes and, as has recently been appreciated, noncoding RNAs including microRNAs (miRNAs). Consistent with their ability to potently influence cancer phenotypes, the regulation of miRNAs by Myc affects virtually all aspects of the Myc oncogenic program, including proliferation, survival, metabolism, angiogenesis, and metastasis. This review will summarize the current understanding of the mechanisms underlying Myc-dependent transcriptional and posttranscriptional control of miRNAs and the resultant effects on tumorigenesis. As miRNAs are integral nodes in the transcriptional network controlled by Myc, modulating their activity represents a promising new approach for cancer therapy.

AB - Hyperactivity of the Myc oncogenic transcription factor dramatically reprograms gene expression to facilitate cellular proliferation and tumorigenesis. To elicit these effects, Myc coordinates the activation and repression of an extensive network of protein-coding genes and, as has recently been appreciated, noncoding RNAs including microRNAs (miRNAs). Consistent with their ability to potently influence cancer phenotypes, the regulation of miRNAs by Myc affects virtually all aspects of the Myc oncogenic program, including proliferation, survival, metabolism, angiogenesis, and metastasis. This review will summarize the current understanding of the mechanisms underlying Myc-dependent transcriptional and posttranscriptional control of miRNAs and the resultant effects on tumorigenesis. As miRNAs are integral nodes in the transcriptional network controlled by Myc, modulating their activity represents a promising new approach for cancer therapy.

KW - microRNA

KW - Myc

KW - Oncogene

KW - Tumor suppressor

UR - http://www.scopus.com/inward/record.url?scp=79952694643&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952694643&partnerID=8YFLogxK

U2 - 10.1177/1947601910377491

DO - 10.1177/1947601910377491

M3 - Article

C2 - 20882107

AN - SCOPUS:79952694643

VL - 1

SP - 568

EP - 575

JO - Genes and Cancer

JF - Genes and Cancer

SN - 1947-6019

IS - 6

ER -