Myasthenic immunoglobulin accelerates acetylcholine receptor degradation

Ing Kao; Daniel B. Drachman

doi:10.1126/science.850793

Myasthenic immunoglobulin accelerates acetylcholine receptor degradation

Ing Kao, Daniel B. Drachman

School of Medicine

Research output: Contribution to journal › Article › peer-review

177 Scopus citations

Abstract

Degradation of acetylcholine receptors by cultured rat skeletal muscle cells was determined from the release of ¹²⁵I from bound ¹²⁵I-labeled α-bungarotoxin. Addition of immunoglobulin from patients with myasthenia gravis to the culture medium accelerated the degradation rate to a mean of 8.51 ± 0.44 percent per hour, compared with the mean control rate of 3.97 ± 0.14 percent per hour (P ≪.001). A similar mechanism may possibly be involved in the autoimmune pathogenesis of myasthenia gravis in man.

Original language	English (US)
Pages (from-to)	527-529
Number of pages	3
Journal	Science
Volume	196
Issue number	4289
DOIs	https://doi.org/10.1126/science.850793
State	Published - 1977

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title = "Myasthenic immunoglobulin accelerates acetylcholine receptor degradation",

abstract = "Degradation of acetylcholine receptors by cultured rat skeletal muscle cells was determined from the release of 125I from bound 125I-labeled α-bungarotoxin. Addition of immunoglobulin from patients with myasthenia gravis to the culture medium accelerated the degradation rate to a mean of 8.51 ± 0.44 percent per hour, compared with the mean control rate of 3.97 ± 0.14 percent per hour (P ≪.001). A similar mechanism may possibly be involved in the autoimmune pathogenesis of myasthenia gravis in man.",

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AU - Drachman, Daniel B.

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AB - Degradation of acetylcholine receptors by cultured rat skeletal muscle cells was determined from the release of 125I from bound 125I-labeled α-bungarotoxin. Addition of immunoglobulin from patients with myasthenia gravis to the culture medium accelerated the degradation rate to a mean of 8.51 ± 0.44 percent per hour, compared with the mean control rate of 3.97 ± 0.14 percent per hour (P ≪.001). A similar mechanism may possibly be involved in the autoimmune pathogenesis of myasthenia gravis in man.

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Myasthenic immunoglobulin accelerates acetylcholine receptor degradation

Abstract

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