Myasthenic immunoglobulin accelerates acetylcholine receptor degradation

Research output: Contribution to journalArticle

Abstract

Degradation of acetylcholine receptors by cultured rat skeletal muscle cells was determined from the release of 125I from bound 125I-labeled α-bungarotoxin. Addition of immunoglobulin from patients with myasthenia gravis to the culture medium accelerated the degradation rate to a mean of 8.51 ± 0.44 percent per hour, compared with the mean control rate of 3.97 ± 0.14 percent per hour (P ≪.001). A similar mechanism may possibly be involved in the autoimmune pathogenesis of myasthenia gravis in man.

Original languageEnglish (US)
Pages (from-to)527-529
Number of pages3
JournalScience
Volume196
Issue number4289
DOIs
StatePublished - Jan 1 1977

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