Myasthenia gravis. Study of humoral immune mechanisms by passive transfer to mice

K. V. Toyka, Daniel B Drachman, Diane Griffin, A. Pestronk, J. A. Winkelstein, K. H. Fishbeck, I. Kao

Research output: Contribution to journalArticle

Abstract

To study the role of humoral factors in the pathogenesis of myasthenia gravis, we employed passive transfer of human serum fractions to mice. Immunoglobulins from 16 patients with myasthenia gravis were injected into mice daily for one to 14 days. Typical myasthenic features of reduction in amplitude of miniature end plate potentials (mean change more than 50%, P

Original languageEnglish (US)
Pages (from-to)125-131
Number of pages7
JournalNew England Journal of Medicine
Volume296
Issue number3
StatePublished - 1977

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Myasthenia Gravis
Miniature Postsynaptic Potentials
Muscle Weakness
Immunoglobulins
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Toyka, K. V., Drachman, D. B., Griffin, D., Pestronk, A., Winkelstein, J. A., Fishbeck, K. H., & Kao, I. (1977). Myasthenia gravis. Study of humoral immune mechanisms by passive transfer to mice. New England Journal of Medicine, 296(3), 125-131.

Myasthenia gravis. Study of humoral immune mechanisms by passive transfer to mice. / Toyka, K. V.; Drachman, Daniel B; Griffin, Diane; Pestronk, A.; Winkelstein, J. A.; Fishbeck, K. H.; Kao, I.

In: New England Journal of Medicine, Vol. 296, No. 3, 1977, p. 125-131.

Research output: Contribution to journalArticle

Toyka, KV, Drachman, DB, Griffin, D, Pestronk, A, Winkelstein, JA, Fishbeck, KH & Kao, I 1977, 'Myasthenia gravis. Study of humoral immune mechanisms by passive transfer to mice', New England Journal of Medicine, vol. 296, no. 3, pp. 125-131.
Toyka, K. V. ; Drachman, Daniel B ; Griffin, Diane ; Pestronk, A. ; Winkelstein, J. A. ; Fishbeck, K. H. ; Kao, I. / Myasthenia gravis. Study of humoral immune mechanisms by passive transfer to mice. In: New England Journal of Medicine. 1977 ; Vol. 296, No. 3. pp. 125-131.
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