Myasthenia Gravis

Research output: Contribution to journalReview articlepeer-review

Abstract

(Second of Two Parts) Clinical Correlations Many of the features of myasthenia gravis that were previously poorly understood can now be explained satisfactorily in terms of the pathogenetic mechanisms outlined in the first part of this review. In this section, certain aspects of the clinical manifestations, diagnostic tests and therapy are re-examined in the light of the present concept of myasthenia as a systemic autoimmune disorder of acetylcholine receptors. Weakness Muscular weakness, one of the cardinal features of myasthenia gravis, results from failure of neuromuscular transmission at many junctions, owing to the reduction of available acetylcholine receptors.27 The decreased number.

Original languageEnglish (US)
Pages (from-to)186-193
Number of pages8
JournalNew England Journal of Medicine
Volume298
Issue number4
DOIs
StatePublished - Jan 26 1978

ASJC Scopus subject areas

  • Medicine(all)

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