Myasthenia gravis: Passive transfer from man to mouse

Klaus V. Toyka, Daniel B. Drachman, Alan Pestronk, Ing Kao

Research output: Contribution to journalArticlepeer-review

Abstract

Daily injections into mice of an ammonium sulfate-precipitated immunoglobulin fraction of serum from patients with my asthenia gravis were carried out for up to 14 days. The mice showed reduced amplitudes of miniature endplate potentials and reduced numbers of acetylcholine receptors at the neuromuscular junctions. Some mice showed typical decremental responses on repetitive nerve stimulation, with reversal by neostigmine. This represents the first evidence of a circulating factor in the serum of patients with myasthenia gravis which on passive transfer reproduces features of the disease in experimental animals.

Original languageEnglish (US)
Pages (from-to)397-399
Number of pages3
JournalScience
Volume190
Issue number4212
DOIs
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • General

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