Myasthenia gravis: Passive transfer from man to mouse

Klaus V. Toyka; Daniel B. Drachman; Alan Pestronk; Ing Kao

doi:10.1126/science.1179220

Myasthenia gravis: Passive transfer from man to mouse

Klaus V. Toyka, Daniel B. Drachman, Alan Pestronk, Ing Kao

School of Medicine

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353 Scopus citations

Abstract

Daily injections into mice of an ammonium sulfate-precipitated immunoglobulin fraction of serum from patients with my asthenia gravis were carried out for up to 14 days. The mice showed reduced amplitudes of miniature endplate potentials and reduced numbers of acetylcholine receptors at the neuromuscular junctions. Some mice showed typical decremental responses on repetitive nerve stimulation, with reversal by neostigmine. This represents the first evidence of a circulating factor in the serum of patients with myasthenia gravis which on passive transfer reproduces features of the disease in experimental animals.

Original language	English (US)
Pages (from-to)	397-399
Number of pages	3
Journal	Science
Volume	190
Issue number	4212
DOIs	https://doi.org/10.1126/science.1179220
State	Published - Jan 1 1975

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Myasthenia gravis: Passive transfer from man to mouse

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