Myasthenia Gravis

Research output: Contribution to journalReview articlepeer-review


MYASTHENIA gravis is a neuromuscular disorder manifested by weakness and fatigability of voluntary muscles. The clinical features were well known by the turn of the century,12 and little has subsequently been added to the classic descriptions of the disease. The similarity between myasthenia gravis and curare poisoning, and the remarkable response of many patients to anticholinesterase drugs,34 first pointed to the neuromuscular junction as the general region of the abnormality. However, the exact site and nature of the process remained elusive, until the development and application of a new set of tools —the neurotoxins derived from certain snake venoms —permitted.

Original languageEnglish (US)
Pages (from-to)136-142
Number of pages7
JournalNew England Journal of Medicine
Issue number3
StatePublished - Jan 19 1978

ASJC Scopus subject areas

  • Medicine(all)


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