(Second of Two Parts) Clinical Correlations Many of the features of myasthenia gravis that were previously poorly understood can now be explained satisfactorily in terms of the pathogenetic mechanisms outlined in the first part of this review. In this section, certain aspects of the clinical manifestations, diagnostic tests and therapy are re-examined in the light of the present concept of myasthenia as a systemic autoimmune disorder of acetylcholine receptors. Weakness Muscular weakness, one of the cardinal features of myasthenia gravis, results from failure of neuromuscular transmission at many junctions, owing to the reduction of available acetylcholine receptors.27 The decreased number.
|Original language||English (US)|
|Number of pages||8|
|Journal||New England Journal of Medicine|
|State||Published - Jan 26 1978|
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