Mutations in panD encoding aspartate decarboxylase are associated with pyrazinamide resistance in Mycobacterium tuberculosis

Agriculture & Biology

• Mycobacterium tuberculosis 58%
• aspartic acid 46%
• mutation 33%
• tuberculosis 18%
• mutants 12%
• Mycobacterium canettii 10%
• coenzyme A 6%
• ribosomal proteins 5%
• resistance mechanisms 5%
• drug therapy 5%
• alanine 5%
• translation (genetics) 4%
• sequence analysis 4%
• genes 3%
• drugs 3%
• biosynthesis 3%
• acids 3%
• genome 2%
• synthesis 2%

Medicine & Life Sciences

• Pyrazinamide 65%
• Mycobacterium tuberculosis 47%
• Mutation 27%
• Multidrug-Resistant Tuberculosis 8%
• Nicotinamidase 6%
• pyrazinoic acid 6%
• pyrazinamide deamidase 6%
• ribosomal protein S1 6%
• Whole Genome Sequencing 4%
• Prodrugs 3%
• Mycobacterium 3%
• Alanine 3%
• DNA Sequence Analysis 3%
• Pharmaceutical Preparations 2%
• Tuberculosis 2%
• Genes 2%
• Enzymes 1%
• In Vitro Techniques 1%

Chemical Compounds

• Aspartate 53%
• Mutation 41%
• Resistance 30%
• Strain 11%
• Pantothenate 8%
• Tuberculostatic Agent 7%
• DNA Sequencing 6%
• Coenzyme A 6%
• Prodrug 5%
• Biosynthesis 4%
• Drug 2%
• Protein 2%
• Acid 1%