Mutations in CIC and FUBP1 contribute to human oligodendroglioma

Chetan Bettegowda, Nishant Agrawal, Yuchen Jiao, Mark Sausen, Laura Delong Wood, Ralph H Hruban, Fausto J Rodriguez, Daniel P. Cahill, Roger McLendon, Gregory J Riggins, Victor E Velculescu, Sueli Mieko Oba-Shinjo, Suely Kazue Nagahashi Marie, Bert Vogelstein, Darell Bigner, Hai Yan, Nickolas Papadopoulos, Kenneth W Kinzler

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Abstract

Oligodendrogliomas are the second most common malignant brain tumor in adults and exhibit characteristic losses of chromosomes 1p and 19q. To identify the molecular genetic basis for this alteration, we performed exomic sequencing of seven tumors. Among other changes, we found that the CIC gene (homolog of the Drosophila gene capicua) on chromosome 19q was somatically mutated in six cases and that the FUBP1 gene [encoding far-upstream element (FUSE) binding protein] on chromosome 1p was somatically mutated in two tumors. Examination of 27 additional oligodendrogliomas revealed 12 and 3 more tumors with mutations of CIC and FUBP1, respectively, 58% of which were predicted to result in truncations of the encoded proteins. These results suggest a critical role for these genes in the biology and pathology of oligodendrocytes.

Original languageEnglish (US)
Pages (from-to)1453-1455
Number of pages3
JournalScience
Volume333
Issue number6048
DOIs
StatePublished - Sep 9 2011

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