Mutational analysis of PINX1 in hereditary prostate cancer

Gregory A. Hawkins, Bao Li Chang, S. Lilly Zheng, Sarah D. Isaacs, Kathleen E. Wiley, Eugene R. Bleecker, Patrick Walsh, Deborah A. Meyers, Jianfeng Xu, William B Isaacs

Research output: Contribution to journalArticle

Abstract

BACKGROUND. Telomerase activity is increased in most tumors. PinX1 has recently been identified as a critical component in regulating telomerase activity. The PinX1 gene is located within chromosomal region 8p22-23, a region associated with LOH and potentially linked to increased prostate cancer risk. METHODS. PINX1 was re-sequenced in 159 hereditary prostate cancer (HPC) probands. Four non-synonymous coding variants were genotyped in 159 HPC families. RESULTS. Thirty-nine polymorphisms were identified in the HPC screening panel. Ten coding polymorphisms were identified, seven (Gln 50His, Leu91Met, Gln206His, Arg 215Ile, Thr220Ala, Ser254Cys, and Glu 414Ala) of which were non-synonymous. The most common variants Thr220Ala and Ser254Cys were not significantly over-transmitted from affected parent to affected offspring. CONCLUSIONS. Based on these results, we conclude that PINX1 is not a major factor for HPC risk.

Original languageEnglish (US)
Pages (from-to)298-302
Number of pages5
JournalProstate
Volume60
Issue number4
DOIs
StatePublished - Sep 1 2004

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Telomerase
Early Detection of Cancer
Prostatic Neoplasms
Familial Prostate cancer
Genes
Neoplasms

Keywords

  • PinX1
  • Polymorphisms
  • Prostate cancer
  • Telomerase

ASJC Scopus subject areas

  • Urology

Cite this

Hawkins, G. A., Chang, B. L., Zheng, S. L., Isaacs, S. D., Wiley, K. E., Bleecker, E. R., ... Isaacs, W. B. (2004). Mutational analysis of PINX1 in hereditary prostate cancer. Prostate, 60(4), 298-302. https://doi.org/10.1002/pros.20075

Mutational analysis of PINX1 in hereditary prostate cancer. / Hawkins, Gregory A.; Chang, Bao Li; Zheng, S. Lilly; Isaacs, Sarah D.; Wiley, Kathleen E.; Bleecker, Eugene R.; Walsh, Patrick; Meyers, Deborah A.; Xu, Jianfeng; Isaacs, William B.

In: Prostate, Vol. 60, No. 4, 01.09.2004, p. 298-302.

Research output: Contribution to journalArticle

Hawkins, GA, Chang, BL, Zheng, SL, Isaacs, SD, Wiley, KE, Bleecker, ER, Walsh, P, Meyers, DA, Xu, J & Isaacs, WB 2004, 'Mutational analysis of PINX1 in hereditary prostate cancer', Prostate, vol. 60, no. 4, pp. 298-302. https://doi.org/10.1002/pros.20075
Hawkins GA, Chang BL, Zheng SL, Isaacs SD, Wiley KE, Bleecker ER et al. Mutational analysis of PINX1 in hereditary prostate cancer. Prostate. 2004 Sep 1;60(4):298-302. https://doi.org/10.1002/pros.20075
Hawkins, Gregory A. ; Chang, Bao Li ; Zheng, S. Lilly ; Isaacs, Sarah D. ; Wiley, Kathleen E. ; Bleecker, Eugene R. ; Walsh, Patrick ; Meyers, Deborah A. ; Xu, Jianfeng ; Isaacs, William B. / Mutational analysis of PINX1 in hereditary prostate cancer. In: Prostate. 2004 ; Vol. 60, No. 4. pp. 298-302.
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AU - Bleecker, Eugene R.

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AB - BACKGROUND. Telomerase activity is increased in most tumors. PinX1 has recently been identified as a critical component in regulating telomerase activity. The PinX1 gene is located within chromosomal region 8p22-23, a region associated with LOH and potentially linked to increased prostate cancer risk. METHODS. PINX1 was re-sequenced in 159 hereditary prostate cancer (HPC) probands. Four non-synonymous coding variants were genotyped in 159 HPC families. RESULTS. Thirty-nine polymorphisms were identified in the HPC screening panel. Ten coding polymorphisms were identified, seven (Gln 50His, Leu91Met, Gln206His, Arg 215Ile, Thr220Ala, Ser254Cys, and Glu 414Ala) of which were non-synonymous. The most common variants Thr220Ala and Ser254Cys were not significantly over-transmitted from affected parent to affected offspring. CONCLUSIONS. Based on these results, we conclude that PINX1 is not a major factor for HPC risk.

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