TY - JOUR
T1 - Mutational analysis of gene families in human cancer
AU - Bardelli, Alberto
AU - Velculescu, Victor E.
N1 - Funding Information:
We apologise to colleagues whose work was not cited owing to space constraints or our oversight. We thank Miriam Martini for help in editing the figures. Supported by The Ludwig Trust, The Pew Charitable Trusts, and NIH grants CA 43460, CA 57345 and CA 62924, The Italian Association for Cancer Research (AIRC) and The Italian University Technology and Research Ministry (MURST).
PY - 2005/2
Y1 - 2005/2
N2 - The completion of the human genome project has marked a new beginning in biomedical sciences. Human cancer is a genetic disease and, accordingly, the field of oncology has been one of the first to be impacted by this historic revolution. Knowledge of the sequence and organization of the human genome facilitates the systematic analysis of the genetic alterations underlying the origin and evolution of tumors. Recent mutational analyses in colorectal and other cancers have focused on examination of gene families involved in signal transduction, such as kinases and phosphatases. This approach has been successful in identifying mutations in a variety of different genes, including the identification of PI3KCA as one of the most commonly mutated oncogenes in human cancer. Such genomic analyses have already demonstrated their utility in basic and clinical cancer research, and are expected to have an important impact on future diagnostic and therapeutic strategies.
AB - The completion of the human genome project has marked a new beginning in biomedical sciences. Human cancer is a genetic disease and, accordingly, the field of oncology has been one of the first to be impacted by this historic revolution. Knowledge of the sequence and organization of the human genome facilitates the systematic analysis of the genetic alterations underlying the origin and evolution of tumors. Recent mutational analyses in colorectal and other cancers have focused on examination of gene families involved in signal transduction, such as kinases and phosphatases. This approach has been successful in identifying mutations in a variety of different genes, including the identification of PI3KCA as one of the most commonly mutated oncogenes in human cancer. Such genomic analyses have already demonstrated their utility in basic and clinical cancer research, and are expected to have an important impact on future diagnostic and therapeutic strategies.
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U2 - 10.1016/j.gde.2004.12.009
DO - 10.1016/j.gde.2004.12.009
M3 - Review article
C2 - 15661527
AN - SCOPUS:12344313069
SN - 0959-437X
VL - 15
SP - 5
EP - 12
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 1
ER -