Abstract
It is now well established that cancer is a genetic disease and that somatic mutations of oncogenes and tumour suppressor genes are the initiators of the carcinogenic process. The phosphatidylinositol 3-kinase signalling pathway has previously been implicated in tumorigenesis, and evidence over the past year suggests a pivotal role for the phosphatidylinositol 3-kinase catalytic subunit, PIK3CA, in human cancers. In this review, we analyse recent reports describing PIK3CA mutations in a variety of human malignancies, and discuss their possible implications for diagnosis and therapy.
Original language | English (US) |
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Pages (from-to) | 455-459 |
Number of pages | 5 |
Journal | British Journal of Cancer |
Volume | 94 |
Issue number | 4 |
DOIs | |
State | Published - Feb 27 2006 |
Keywords
- p110α
- PI3K
- PIK3CA
- Somatic mutations
ASJC Scopus subject areas
- Cancer Research
- Oncology