Mutation of the PIK3CA oncogene in human cancers

B. Karakas, K. E. Bachman, B. H. Park

Research output: Contribution to journalArticlepeer-review

Abstract

It is now well established that cancer is a genetic disease and that somatic mutations of oncogenes and tumour suppressor genes are the initiators of the carcinogenic process. The phosphatidylinositol 3-kinase signalling pathway has previously been implicated in tumorigenesis, and evidence over the past year suggests a pivotal role for the phosphatidylinositol 3-kinase catalytic subunit, PIK3CA, in human cancers. In this review, we analyse recent reports describing PIK3CA mutations in a variety of human malignancies, and discuss their possible implications for diagnosis and therapy.

Original languageEnglish (US)
Pages (from-to)455-459
Number of pages5
JournalBritish Journal of Cancer
Volume94
Issue number4
DOIs
StatePublished - Feb 27 2006

Keywords

  • p110α
  • PI3K
  • PIK3CA
  • Somatic mutations

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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