Mutated chromatin regulatory factors as tumor drivers in cancer

Carl Koschmann, Felipe J. Nunez, Flor Mendez, Jacqueline A. Brosnan-Cashman, Alan K. Meeker, Pedro R. Lowenstein, Maria G. Castro

Research output: Contribution to journalReview articlepeer-review

Abstract

Genes encoding proteins that regulate chromatin structure and DNA modifications [i.e., chromatin regulatory factors (CRF)] and genes encoding histone proteins harbor recurrent mutations in most human cancers. These mutations lead to modifications in tumor chromatin and DNA structure and an altered epigenetic state that contribute to tumorigenesis. Mutated CRFs have now been identified in most types of cancer and are increasingly regarded as novel therapeutic targets. In this review, we discuss DNA alterations in CRFs and how these influence tumor chromatin structure and function, which in turn leads to tumorigenesis. We also discuss the clinical implications and review concepts of targeted treatments for these mutations. Continued research on CRF mutations will be critical for our future understanding of cancer biology and the development and implementation of novel cancer therapies.

Original languageEnglish (US)
Pages (from-to)227-233
Number of pages7
JournalCancer Research
Volume77
Issue number2
DOIs
StatePublished - Jan 15 2017

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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