Mutated CALR: Tails from the crypt

Jerry L. Spivak

doi:10.1182/blood-2019-04-901132

Mutated CALR: Tails from the crypt

Jerry L. Spivak

School of Medicine

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

The discovery by exome sequencing that calreticulin (CALR) gene mutations are important gain-of-function myeloproliferative neoplasm (MPN) driver mutations^1,2 was as inexplicable as it was unexpected. In this issue of Blood, Pecquet et al³ report that mutated CALR behaves like a rogue chaperone, usurping the role of JAK2 and promiscuously transporting immature or trafficdefective thrombopoietin receptors (TpoRs) to the cell surface from the endoplasmic reticulum (ER) (see figure).

Original language	English (US)
Pages (from-to)	2630-2631
Number of pages	2
Journal	Blood
Volume	133
Issue number	25
DOIs	https://doi.org/10.1182/blood-2019-04-901132
State	Published - 2019

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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title = "Mutated CALR: Tails from the crypt",

abstract = "The discovery by exome sequencing that calreticulin (CALR) gene mutations are important gain-of-function myeloproliferative neoplasm (MPN) driver mutations1,2 was as inexplicable as it was unexpected. In this issue of Blood, Pecquet et al3 report that mutated CALR behaves like a rogue chaperone, usurping the role of JAK2 and promiscuously transporting immature or trafficdefective thrombopoietin receptors (TpoRs) to the cell surface from the endoplasmic reticulum (ER) (see figure).",

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AB - The discovery by exome sequencing that calreticulin (CALR) gene mutations are important gain-of-function myeloproliferative neoplasm (MPN) driver mutations1,2 was as inexplicable as it was unexpected. In this issue of Blood, Pecquet et al3 report that mutated CALR behaves like a rogue chaperone, usurping the role of JAK2 and promiscuously transporting immature or trafficdefective thrombopoietin receptors (TpoRs) to the cell surface from the endoplasmic reticulum (ER) (see figure).

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Mutated CALR: Tails from the crypt

Abstract

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