Mutant metabolic enzymes are at the origin of gliomas

Hai Yan; Darell D. Bigner; Victor Velculescu; D. Williams Parsons

doi:10.1158/0008-5472.CAN-09-2650

Mutant metabolic enzymes are at the origin of gliomas

Hai Yan, Darell D. Bigner, Victor Velculescu, D. Williams Parsons

School of Medicine

Research output: Contribution to journal › Review article › peer-review

116 Scopus citations

Abstract

Mutations of the isocitrate dehydrogenase (IDH) metabolic enzymes IDH1 and IDH2 have been found to be frequent and early genetic alterations in astrocytomas and oligodendrogliomas. All mutations identified to date affect a single amino acid located within the isocitrate binding site (R132 of IDH1 and the analogous R172 residue of IDH2). IDH1 and IDH2 mutations define a specific subtype of gliomas and may have significant utility for the diagnosis, prognosis, and treatment of patients with these tumors.

Original language	English (US)
Pages (from-to)	9157-9159
Number of pages	3
Journal	Cancer Research
Volume	69
Issue number	24
DOIs	https://doi.org/10.1158/0008-5472.CAN-09-2650
State	Published - Dec 15 2009

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1158/0008-5472.CAN-09-2650

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abstract = "Mutations of the isocitrate dehydrogenase (IDH) metabolic enzymes IDH1 and IDH2 have been found to be frequent and early genetic alterations in astrocytomas and oligodendrogliomas. All mutations identified to date affect a single amino acid located within the isocitrate binding site (R132 of IDH1 and the analogous R172 residue of IDH2). IDH1 and IDH2 mutations define a specific subtype of gliomas and may have significant utility for the diagnosis, prognosis, and treatment of patients with these tumors.",

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AU - Yan, Hai

AU - Bigner, Darell D.

AU - Velculescu, Victor

AU - Parsons, D. Williams

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Y1 - 2009/12/15

N2 - Mutations of the isocitrate dehydrogenase (IDH) metabolic enzymes IDH1 and IDH2 have been found to be frequent and early genetic alterations in astrocytomas and oligodendrogliomas. All mutations identified to date affect a single amino acid located within the isocitrate binding site (R132 of IDH1 and the analogous R172 residue of IDH2). IDH1 and IDH2 mutations define a specific subtype of gliomas and may have significant utility for the diagnosis, prognosis, and treatment of patients with these tumors.

AB - Mutations of the isocitrate dehydrogenase (IDH) metabolic enzymes IDH1 and IDH2 have been found to be frequent and early genetic alterations in astrocytomas and oligodendrogliomas. All mutations identified to date affect a single amino acid located within the isocitrate binding site (R132 of IDH1 and the analogous R172 residue of IDH2). IDH1 and IDH2 mutations define a specific subtype of gliomas and may have significant utility for the diagnosis, prognosis, and treatment of patients with these tumors.

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Mutant metabolic enzymes are at the origin of gliomas

Abstract

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