Mutant metabolic enzymes are at the origin of gliomas

Hai Yan, Darell D. Bigner, Victor Velculescu, D. Williams Parsons

Research output: Contribution to journalReview articlepeer-review


Mutations of the isocitrate dehydrogenase (IDH) metabolic enzymes IDH1 and IDH2 have been found to be frequent and early genetic alterations in astrocytomas and oligodendrogliomas. All mutations identified to date affect a single amino acid located within the isocitrate binding site (R132 of IDH1 and the analogous R172 residue of IDH2). IDH1 and IDH2 mutations define a specific subtype of gliomas and may have significant utility for the diagnosis, prognosis, and treatment of patients with these tumors.

Original languageEnglish (US)
Pages (from-to)9157-9159
Number of pages3
JournalCancer Research
Issue number24
StatePublished - Dec 15 2009

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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