The gene most commonly altered in human glioblastomas is the epidermal growth factor receptor (EGFR). We profiled transcripts induced by mutant EGFR to better understand its role in tumor progression. The pattern found suggested enhanced tumor invasion. The highly induced genes included extracellular matrix components, metalloproteases, and a serine protease. We confirmed that mutant EGFR did make glioblastoma cells both more motile and invasive using in vitro assays. Furthermore, inhibitors of EGFR (OSI-774 and Tyrphostin AG1478) selectively downregulated these molecular effectors in glioblastoma cells, eliminating enhanced invasion.
|Original language||English (US)|
|Number of pages||5|
|State||Published - Jun 15 2002|
ASJC Scopus subject areas
- Cancer Research