Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion

Anita Lal, Chad A. Glazer, Holly M. Martinson, Henry S. Friedman, Gary E. Archer, John H. Sampson, Gregory J. Riggins

Research output: Contribution to journalArticle

Abstract

The gene most commonly altered in human glioblastomas is the epidermal growth factor receptor (EGFR). We profiled transcripts induced by mutant EGFR to better understand its role in tumor progression. The pattern found suggested enhanced tumor invasion. The highly induced genes included extracellular matrix components, metalloproteases, and a serine protease. We confirmed that mutant EGFR did make glioblastoma cells both more motile and invasive using in vitro assays. Furthermore, inhibitors of EGFR (OSI-774 and Tyrphostin AG1478) selectively downregulated these molecular effectors in glioblastoma cells, eliminating enhanced invasion.

Original languageEnglish (US)
Pages (from-to)3335-3339
Number of pages5
JournalCancer Research
Volume62
Issue number12
StatePublished - Jun 15 2002

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Lal, A., Glazer, C. A., Martinson, H. M., Friedman, H. S., Archer, G. E., Sampson, J. H., & Riggins, G. J. (2002). Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion. Cancer Research, 62(12), 3335-3339.