Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion

Anita Lal; Chad A. Glazer; Holly M. Martinson; Henry S. Friedman; Gary E. Archer; John H. Sampson; Gregory J. Riggins

Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion

Anita Lal, Chad A. Glazer, Holly M. Martinson, Henry S. Friedman, Gary E. Archer, John H. Sampson, Gregory J. Riggins

Research output: Contribution to journal › Article › peer-review

Abstract

The gene most commonly altered in human glioblastomas is the epidermal growth factor receptor (EGFR). We profiled transcripts induced by mutant EGFR to better understand its role in tumor progression. The pattern found suggested enhanced tumor invasion. The highly induced genes included extracellular matrix components, metalloproteases, and a serine protease. We confirmed that mutant EGFR did make glioblastoma cells both more motile and invasive using in vitro assays. Furthermore, inhibitors of EGFR (OSI-774 and Tyrphostin AG1478) selectively downregulated these molecular effectors in glioblastoma cells, eliminating enhanced invasion.

Original language	English (US)
Pages (from-to)	3335-3339
Number of pages	5
Journal	Cancer Research
Volume	62
Issue number	12
State	Published - Jun 15 2002
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

@article{cc02d0a0002b4e5282285bbf90c4cb33,

title = "Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion",

abstract = "The gene most commonly altered in human glioblastomas is the epidermal growth factor receptor (EGFR). We profiled transcripts induced by mutant EGFR to better understand its role in tumor progression. The pattern found suggested enhanced tumor invasion. The highly induced genes included extracellular matrix components, metalloproteases, and a serine protease. We confirmed that mutant EGFR did make glioblastoma cells both more motile and invasive using in vitro assays. Furthermore, inhibitors of EGFR (OSI-774 and Tyrphostin AG1478) selectively downregulated these molecular effectors in glioblastoma cells, eliminating enhanced invasion.",

author = "Anita Lal and Glazer, {Chad A.} and Martinson, {Holly M.} and Friedman, {Henry S.} and Archer, {Gary E.} and Sampson, {John H.} and Riggins, {Gregory J.}",

year = "2002",

month = jun,

day = "15",

language = "English (US)",

volume = "62",

pages = "3335--3339",

journal = "Cancer Research",

issn = "0008-5472",

publisher = "American Association for Cancer Research Inc.",

number = "12",

}

TY - JOUR

T1 - Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion

AU - Lal, Anita

AU - Glazer, Chad A.

AU - Martinson, Holly M.

AU - Friedman, Henry S.

AU - Archer, Gary E.

AU - Sampson, John H.

AU - Riggins, Gregory J.

PY - 2002/6/15

Y1 - 2002/6/15

N2 - The gene most commonly altered in human glioblastomas is the epidermal growth factor receptor (EGFR). We profiled transcripts induced by mutant EGFR to better understand its role in tumor progression. The pattern found suggested enhanced tumor invasion. The highly induced genes included extracellular matrix components, metalloproteases, and a serine protease. We confirmed that mutant EGFR did make glioblastoma cells both more motile and invasive using in vitro assays. Furthermore, inhibitors of EGFR (OSI-774 and Tyrphostin AG1478) selectively downregulated these molecular effectors in glioblastoma cells, eliminating enhanced invasion.

AB - The gene most commonly altered in human glioblastomas is the epidermal growth factor receptor (EGFR). We profiled transcripts induced by mutant EGFR to better understand its role in tumor progression. The pattern found suggested enhanced tumor invasion. The highly induced genes included extracellular matrix components, metalloproteases, and a serine protease. We confirmed that mutant EGFR did make glioblastoma cells both more motile and invasive using in vitro assays. Furthermore, inhibitors of EGFR (OSI-774 and Tyrphostin AG1478) selectively downregulated these molecular effectors in glioblastoma cells, eliminating enhanced invasion.

UR - http://www.scopus.com/inward/record.url?scp=0037096945&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037096945&partnerID=8YFLogxK

M3 - Article

C2 - 12067969

AN - SCOPUS:0037096945

SN - 0008-5472

VL - 62

SP - 3335

EP - 3339

JO - Cancer Research

JF - Cancer Research

IS - 12

ER -

Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this