TY - JOUR
T1 - Mutagenic drinking water and risk of male esophageal cancer
T2 - A population-based case-control study
AU - Tao, Xuguang
AU - Zhu, Huigang
AU - Matanoski, Genevieve M.
N1 - Funding Information:
This work was supported by the Shanghai Environmental Protection Agency, Shanghai, China, and was finished during the tenure of a Research Training Fellowship awarded to Xuguang Tao (IARC/R.2170, 1993-1994) by the International Agency of Research on Cancer, Lyon, France.
PY - 1999/9/1
Y1 - 1999/9/1
N2 - Drinking mutagenic downstream water from the Huangpu River was hypothesized to have increased the risk for male esophageal cancer in Shanghai, China. The authors conducted a population-based case-control study of a total of 71 esophageal cancer deaths and 1,122 controls collected during a 5-year follow-up period, 1984-1988, from four male cohorts born before January 1, 1944, living in four communities consuming water with different mutagenicities in the Shanghai area. The controls represented a 1% random sample of the defined living cohorts selected at the end of each of the 5 years of follow-up. Logistic regression showed an odds ratio of 2.77 (95% confidence interval: 1.52, 5.03) for drinking mutagenic downstream water from the river versus drinking nonmutagenic upstream water after controlling for possible confounders including age, disease history (hepatitis, cirrhosis, schistosomiasis, digestive tract ulcer), hazardous occupational history, pesticide exposure, lifestyle factors (cigarette smoking, tea intake, and alcohol intake), dietary habits (intake of pickled vegetables, maize, peanuts, and cured meat), education, poverty, urban environment, and water chlorination.
AB - Drinking mutagenic downstream water from the Huangpu River was hypothesized to have increased the risk for male esophageal cancer in Shanghai, China. The authors conducted a population-based case-control study of a total of 71 esophageal cancer deaths and 1,122 controls collected during a 5-year follow-up period, 1984-1988, from four male cohorts born before January 1, 1944, living in four communities consuming water with different mutagenicities in the Shanghai area. The controls represented a 1% random sample of the defined living cohorts selected at the end of each of the 5 years of follow-up. Logistic regression showed an odds ratio of 2.77 (95% confidence interval: 1.52, 5.03) for drinking mutagenic downstream water from the river versus drinking nonmutagenic upstream water after controlling for possible confounders including age, disease history (hepatitis, cirrhosis, schistosomiasis, digestive tract ulcer), hazardous occupational history, pesticide exposure, lifestyle factors (cigarette smoking, tea intake, and alcohol intake), dietary habits (intake of pickled vegetables, maize, peanuts, and cured meat), education, poverty, urban environment, and water chlorination.
KW - Case-control studies
KW - Chlorine compounds
KW - Esophageal neoplasms
KW - Mutagenicity tests
KW - Pesticides
KW - Risk
KW - Smoking
KW - Water pollution
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U2 - 10.1093/oxfordjournals.aje.a010032
DO - 10.1093/oxfordjournals.aje.a010032
M3 - Article
C2 - 10472943
AN - SCOPUS:0033199481
SN - 0002-9262
VL - 150
SP - 443
EP - 452
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 5
ER -