Musculoskeletal Effects of Cancer and Cancer Treatment

Rosanna Wustrack, Sandesh S. Rao, Carol D. Morris

Research output: Contribution to journalReview articlepeer-review


Improvements in cancer treatment have led to prolonged survival and increased rates of cure. An estimated 14 million cancer survivors live in the United States. The cornerstones of cancer treatment, including radiation, chemotherapy, and surgery, give rise to a host of chronic health conditions, some of which affect the musculoskeletal system. As survivorship continues to improve, orthopaedic surgeons across all subspecialties will be tasked with managing these complications of treatment. This article reviews orthopaedic health concerns secondary to cancer treatment that are likely to present to orthopaedic surgeons for evaluation, such as osteoporosis, osteonecrosis, secondary malignancies, radiation-associated fractures, exercise tolerance, and perioperative evaluation.

Original languageEnglish (US)
Pages (from-to)E716-E728
JournalJournal of the American Academy of Orthopaedic Surgeons
Issue number16
StatePublished - Aug 15 2020

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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