Muscle, Tendon and Ligament in Osteogenesis Imperfecta

Muscle, tendon, and ligament injuries in osteogenesis imperfect (OI) are frequent. These may occur with minimal injury and often involve multiple joints. General muscle weakness is also a frequent complaint of patients. In fact, impaired muscle function has been confirmed in studies in animal models of OI. Patients with OI tend to have joint laxity, which may predispose to injury. These injuries reflect the altered collagen content of muscle, tendons, and ligaments. Published surgical experience is limited; however, recent reports have detailed successful use of allograft techniques to correct tendon and ligament injuries.