Muscle Fatigue from Losing Your PHD

Chi V. Dang, Ping Gao

Research output: Contribution to journalArticle

Abstract

Prolyl hydroxylases (PHDs) sense oxygen, regulate levels of hypoxia-inducible factors (HIFs), and permit hypoxic adaptation. A new study by Aragones et al. (2008) demonstrates that mice lacking skeletal muscle PHD1 have decreased exercise tolerance and oxygen consumption but remarkably tolerate ischemia in a HIF-2α- and PPARα-dependent fashion.

Original languageEnglish (US)
Pages (from-to)191-192
Number of pages2
JournalCell Metabolism
Volume7
Issue number3
DOIs
StatePublished - Mar 5 2008

Fingerprint

Prolyl Hydroxylases
Muscle Fatigue
Peroxisome Proliferator-Activated Receptors
Exercise Tolerance
Oxygen Consumption
Skeletal Muscle
Ischemia
Oxygen
endothelial PAS domain-containing protein 1
Hypoxia

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

Cite this

Muscle Fatigue from Losing Your PHD. / Dang, Chi V.; Gao, Ping.

In: Cell Metabolism, Vol. 7, No. 3, 05.03.2008, p. 191-192.

Research output: Contribution to journalArticle

Dang, Chi V. ; Gao, Ping. / Muscle Fatigue from Losing Your PHD. In: Cell Metabolism. 2008 ; Vol. 7, No. 3. pp. 191-192.
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