Prolyl hydroxylases (PHDs) sense oxygen, regulate levels of hypoxia-inducible factors (HIFs), and permit hypoxic adaptation. A new study by Aragones et al. (2008) demonstrates that mice lacking skeletal muscle PHD1 have decreased exercise tolerance and oxygen consumption but remarkably tolerate ischemia in a HIF-2α- and PPARα-dependent fashion.
|Original language||English (US)|
|Number of pages||2|
|State||Published - Mar 5 2008|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology