Muscle Fatigue from Losing Your PHD

Chi V. Dang; Ping Gao

doi:10.1016/j.cmet.2008.02.007

Muscle Fatigue from Losing Your PHD

Chi V. Dang, Ping Gao

School of Medicine

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Prolyl hydroxylases (PHDs) sense oxygen, regulate levels of hypoxia-inducible factors (HIFs), and permit hypoxic adaptation. A new study by Aragones et al. (2008) demonstrates that mice lacking skeletal muscle PHD1 have decreased exercise tolerance and oxygen consumption but remarkably tolerate ischemia in a HIF-2α- and PPARα-dependent fashion.

Original language	English (US)
Pages (from-to)	191-192
Number of pages	2
Journal	Cell Metabolism
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/j.cmet.2008.02.007
State	Published - Mar 5 2008

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2008.02.007

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title = "Muscle Fatigue from Losing Your PHD",

abstract = "Prolyl hydroxylases (PHDs) sense oxygen, regulate levels of hypoxia-inducible factors (HIFs), and permit hypoxic adaptation. A new study by Aragones et al. (2008) demonstrates that mice lacking skeletal muscle PHD1 have decreased exercise tolerance and oxygen consumption but remarkably tolerate ischemia in a HIF-2α- and PPARα-dependent fashion.",

author = "Dang, {Chi V.} and Ping Gao",

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AU - Dang, Chi V.

AU - Gao, Ping

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N2 - Prolyl hydroxylases (PHDs) sense oxygen, regulate levels of hypoxia-inducible factors (HIFs), and permit hypoxic adaptation. A new study by Aragones et al. (2008) demonstrates that mice lacking skeletal muscle PHD1 have decreased exercise tolerance and oxygen consumption but remarkably tolerate ischemia in a HIF-2α- and PPARα-dependent fashion.

AB - Prolyl hydroxylases (PHDs) sense oxygen, regulate levels of hypoxia-inducible factors (HIFs), and permit hypoxic adaptation. A new study by Aragones et al. (2008) demonstrates that mice lacking skeletal muscle PHD1 have decreased exercise tolerance and oxygen consumption but remarkably tolerate ischemia in a HIF-2α- and PPARα-dependent fashion.

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M3 - Short survey

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AN - SCOPUS:39649116229

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JO - Cell Metabolism

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Muscle Fatigue from Losing Your PHD

Abstract

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