Muscle Fatigue from Losing Your PHD

Chi V. Dang, Ping Gao

Research output: Contribution to journalShort surveypeer-review

Abstract

Prolyl hydroxylases (PHDs) sense oxygen, regulate levels of hypoxia-inducible factors (HIFs), and permit hypoxic adaptation. A new study by Aragones et al. (2008) demonstrates that mice lacking skeletal muscle PHD1 have decreased exercise tolerance and oxygen consumption but remarkably tolerate ischemia in a HIF-2α- and PPARα-dependent fashion.

Original languageEnglish (US)
Pages (from-to)191-192
Number of pages2
JournalCell Metabolism
Volume7
Issue number3
DOIs
StatePublished - Mar 5 2008

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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