Muscle-derived stem cells: important players in peripheral nerve repair

Leila Musavi, Gerald Brandacher, Ahmet Hoke, Halley Darrach, W P Andrew Lee, Anand Kumar, Joseph Lopez

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: Stem cell therapy for peripheral nerve repair is a rapidly evolving field in regenerative medicine. Although most studies to date have investigated stem cells originating from bone marrow or adipose, skeletal muscle has recently been recognized as an abundant and easily accessible source of stem cells. Muscle-derived stem cells (MDSCs) are a diverse population of multipotent cells with pronounced antioxidant and regenerative capacity. Areas covered: The current literature on the various roles MDSCs serve within the micro- and macro-environment of nerve injury. Furthermore, the exciting new research that is establishing MDSC-cellular therapy as an important therapeutic modality to improve peripheral nerve regeneration. Expert opinion: MDSCs are a promising therapeutic agent for the repair of peripheral nerves; MDSCs not only undergo gliogenesis and angiogenesis, but they also orchestrate larger pro-regenerative host responses. However, the isolation, transformation, and in-vivo behavior of MDSCs require further evaluation prior to clinical application.

Original languageEnglish (US)
Pages (from-to)1009-1016
Number of pages8
JournalExpert Opinion on Therapeutic Targets
Volume22
Issue number12
DOIs
StatePublished - Dec 1 2018

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Keywords

  • muscle-derived stem cells
  • nerve regeneration
  • peripheral nerve repair
  • Schwann cells
  • Stem cell therapy

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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