Muscle-derived stem cells

important players in peripheral nerve repair

Leila Musavi, Gerald Brandacher, Ahmet Hoke, Halley Darrach, W P Andrew Lee, Anand Kumar, Joseph Lopez

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: Stem cell therapy for peripheral nerve repair is a rapidly evolving field in regenerative medicine. Although most studies to date have investigated stem cells originating from bone marrow or adipose, skeletal muscle has recently been recognized as an abundant and easily accessible source of stem cells. Muscle-derived stem cells (MDSCs) are a diverse population of multipotent cells with pronounced antioxidant and regenerative capacity. Areas covered: The current literature on the various roles MDSCs serve within the micro- and macro-environment of nerve injury. Furthermore, the exciting new research that is establishing MDSC-cellular therapy as an important therapeutic modality to improve peripheral nerve regeneration. Expert opinion: MDSCs are a promising therapeutic agent for the repair of peripheral nerves; MDSCs not only undergo gliogenesis and angiogenesis, but they also orchestrate larger pro-regenerative host responses. However, the isolation, transformation, and in-vivo behavior of MDSCs require further evaluation prior to clinical application.

Original languageEnglish (US)
Pages (from-to)1009-1016
Number of pages8
JournalExpert Opinion on Therapeutic Targets
Volume22
Issue number12
DOIs
StatePublished - Dec 1 2018

Fingerprint

Stem cells
Peripheral Nerves
Muscle
Repair
Stem Cells
Muscles
Cell- and Tissue-Based Therapy
Nerve Regeneration
Regenerative Medicine
Expert Testimony
Macros
Bone
Skeletal Muscle
Antioxidants
Bone Marrow
Cells
Wounds and Injuries
Therapeutics
Research
Population

Keywords

  • muscle-derived stem cells
  • nerve regeneration
  • peripheral nerve repair
  • Schwann cells
  • Stem cell therapy

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Muscle-derived stem cells : important players in peripheral nerve repair. / Musavi, Leila; Brandacher, Gerald; Hoke, Ahmet; Darrach, Halley; Lee, W P Andrew; Kumar, Anand; Lopez, Joseph.

In: Expert Opinion on Therapeutic Targets, Vol. 22, No. 12, 01.12.2018, p. 1009-1016.

Research output: Contribution to journalArticle

Musavi, Leila ; Brandacher, Gerald ; Hoke, Ahmet ; Darrach, Halley ; Lee, W P Andrew ; Kumar, Anand ; Lopez, Joseph. / Muscle-derived stem cells : important players in peripheral nerve repair. In: Expert Opinion on Therapeutic Targets. 2018 ; Vol. 22, No. 12. pp. 1009-1016.
@article{b14b0e56a00b4c3eb43cf95b390bd095,
title = "Muscle-derived stem cells: important players in peripheral nerve repair",
abstract = "INTRODUCTION: Stem cell therapy for peripheral nerve repair is a rapidly evolving field in regenerative medicine. Although most studies to date have investigated stem cells originating from bone marrow or adipose, skeletal muscle has recently been recognized as an abundant and easily accessible source of stem cells. Muscle-derived stem cells (MDSCs) are a diverse population of multipotent cells with pronounced antioxidant and regenerative capacity. Areas covered: The current literature on the various roles MDSCs serve within the micro- and macro-environment of nerve injury. Furthermore, the exciting new research that is establishing MDSC-cellular therapy as an important therapeutic modality to improve peripheral nerve regeneration. Expert opinion: MDSCs are a promising therapeutic agent for the repair of peripheral nerves; MDSCs not only undergo gliogenesis and angiogenesis, but they also orchestrate larger pro-regenerative host responses. However, the isolation, transformation, and in-vivo behavior of MDSCs require further evaluation prior to clinical application.",
keywords = "muscle-derived stem cells, nerve regeneration, peripheral nerve repair, Schwann cells, Stem cell therapy",
author = "Leila Musavi and Gerald Brandacher and Ahmet Hoke and Halley Darrach and Lee, {W P Andrew} and Anand Kumar and Joseph Lopez",
year = "2018",
month = "12",
day = "1",
doi = "10.1080/14728222.2018.1539706",
language = "English (US)",
volume = "22",
pages = "1009--1016",
journal = "Expert Opinion on Therapeutic Targets",
issn = "1472-8222",
publisher = "Informa Healthcare",
number = "12",

}

TY - JOUR

T1 - Muscle-derived stem cells

T2 - important players in peripheral nerve repair

AU - Musavi, Leila

AU - Brandacher, Gerald

AU - Hoke, Ahmet

AU - Darrach, Halley

AU - Lee, W P Andrew

AU - Kumar, Anand

AU - Lopez, Joseph

PY - 2018/12/1

Y1 - 2018/12/1

N2 - INTRODUCTION: Stem cell therapy for peripheral nerve repair is a rapidly evolving field in regenerative medicine. Although most studies to date have investigated stem cells originating from bone marrow or adipose, skeletal muscle has recently been recognized as an abundant and easily accessible source of stem cells. Muscle-derived stem cells (MDSCs) are a diverse population of multipotent cells with pronounced antioxidant and regenerative capacity. Areas covered: The current literature on the various roles MDSCs serve within the micro- and macro-environment of nerve injury. Furthermore, the exciting new research that is establishing MDSC-cellular therapy as an important therapeutic modality to improve peripheral nerve regeneration. Expert opinion: MDSCs are a promising therapeutic agent for the repair of peripheral nerves; MDSCs not only undergo gliogenesis and angiogenesis, but they also orchestrate larger pro-regenerative host responses. However, the isolation, transformation, and in-vivo behavior of MDSCs require further evaluation prior to clinical application.

AB - INTRODUCTION: Stem cell therapy for peripheral nerve repair is a rapidly evolving field in regenerative medicine. Although most studies to date have investigated stem cells originating from bone marrow or adipose, skeletal muscle has recently been recognized as an abundant and easily accessible source of stem cells. Muscle-derived stem cells (MDSCs) are a diverse population of multipotent cells with pronounced antioxidant and regenerative capacity. Areas covered: The current literature on the various roles MDSCs serve within the micro- and macro-environment of nerve injury. Furthermore, the exciting new research that is establishing MDSC-cellular therapy as an important therapeutic modality to improve peripheral nerve regeneration. Expert opinion: MDSCs are a promising therapeutic agent for the repair of peripheral nerves; MDSCs not only undergo gliogenesis and angiogenesis, but they also orchestrate larger pro-regenerative host responses. However, the isolation, transformation, and in-vivo behavior of MDSCs require further evaluation prior to clinical application.

KW - muscle-derived stem cells

KW - nerve regeneration

KW - peripheral nerve repair

KW - Schwann cells

KW - Stem cell therapy

UR - http://www.scopus.com/inward/record.url?scp=85056737938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056737938&partnerID=8YFLogxK

U2 - 10.1080/14728222.2018.1539706

DO - 10.1080/14728222.2018.1539706

M3 - Article

VL - 22

SP - 1009

EP - 1016

JO - Expert Opinion on Therapeutic Targets

JF - Expert Opinion on Therapeutic Targets

SN - 1472-8222

IS - 12

ER -