Muscle biopsy in the evaluation of patients with modestly elevated creatine kinase levels

Zachary Simmons, B. Lee Peterlin, Philip J. Boyer, Javad Towfighi

Research output: Contribution to journalArticle

Abstract

The utility of muscle biopsy in patients with modest elevations of serum creatine kinase (CK) level but normal neurological examinations and nondiagnostic electrodiagnostic studies is uncertain. We performed systematic, extensive studies on muscle biopsies of 20 such patients. A definitive diagnosis was arrived at in only 1 by histochemical studies, although 4 others demonstrated minor myopathic changes. Biochemical evaluation led to a diagnosis in an additional 5. Muscle biopsy is useful for evaluating such patients, but extensive studies of the muscle are necessary.

Original languageEnglish (US)
Pages (from-to)242-244
Number of pages3
JournalMuscle and Nerve
Volume27
Issue number2
DOIs
StatePublished - Feb 1 2003

Keywords

  • Creatine kinase
  • HyperCKemia
  • Metabolic myopathy
  • Muscle biopsy
  • Myopathy

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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