Muscarinic binding in suicides

Charles A. Kaufmann, J. Christian Gillin, Brenda Hill, Thomas O'Laughlin, Ingrid Phillips, Joel E. Kleinman, Richard J. Wyatt

Research output: Contribution to journalArticlepeer-review

Abstract

Supersensitive muscarinic cholinergic receptors may underlie mood, neuroendocrine, and sleep disturbances in depression. To test this hypothesis, we examined muscarinic binding sites in the brains of suicides and controls in a matched-pair design, using the radioligand 3H-quinuclidinyl benzilate (ONB) and focusing on regions (frontal cortex, hypothalamus, and pons) mediating those functions. Receptor densities and binding affinities did not differ between suicide and control brains in any brain region studied, although there was a trend for both density and affinity to be lower in hypothalami from suicides. We discuss the implications of these findings for the cholinergic-adrenergic balance hypothesis of depression and the methodological limitations of our preliminary study.

Original languageEnglish (US)
Pages (from-to)47-55
Number of pages9
JournalPsychiatry research
Volume12
Issue number1
DOIs
StatePublished - May 1984
Externally publishedYes

Keywords

  • Suicide
  • acetylcholine
  • depression
  • muscarinic receptor

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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