Muscarinic Acetylcholine Receptors in Alzheimer's Disease: In Vivo Imaging With Iodine 123—Labeled 3-Quinuclidinyl-4-Iodobenzilate and Emission Tomography

B. Leonard Holman, Raymond E. Gibson, Thomas C. Hill, William C. Eckelman, Marilyn Albert, Richard C. Reba

Research output: Contribution to journalArticlepeer-review

Abstract

In vivo imaging of muscarinic acetylcholine receptor binding function in a patient with Alzheimer's disease, using single-photon emission computed tomography and iodine 123-labeled 3-quinuclidinyl-4-iodobenzilate (123I-QNB), and perfusion imaging using123I-N-isopropyl p-iodoamphetamine are described. A profound decrease in perfusion to the posterior temporal and parietal cortex and a more uniform uptake of123I-QNB throughout the cerebral cortex were observed. The123I-QNB activity ratio was reduced compared with that of a normal age-matched subject, suggesting a moderate impairment in muscarinic receptor binding function in Alzheimer's disease. Furthermore, and more importantly, our study demonstrates that images of in vivo receptor binding can be obtained easily and nontraumatically using123I-QNB and single-photon emission computed tomography.

Original languageEnglish (US)
Pages (from-to)3063-3066
Number of pages4
JournalJAMA: The Journal of the American Medical Association
Volume254
Issue number21
DOIs
StatePublished - Dec 6 1985
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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