Murine type C viral envelope glycoprotein gp69/71 and lupus like glomerulonephritis of New Zealand mice. An immunoperoxidase study

M. Imamura, R. C. Mellors, M. Strand, J. T. August

Research output: Contribution to journalArticle

Abstract

The location of murine Type C viral envelope glycoprotein antigen in the glomerulonephritic kidneys of NZB and NZB/NZW F1 hybrid mice was analyzed by the indirect immunoperoxidase technique at light and electron microscopic levels. Immune complex deposits of the glycoprotein antigen were present in the glomeruli in mesangial and subepithelial sites. In addition to the glomerular depositions, viral envelope antigen was also present at the brush border of proximal tubular epithelial cells and in lymphoid cells infiltrating the kidneys of these mice.

Original languageEnglish (US)
Pages (from-to)375-386
Number of pages12
JournalAmerican Journal of Pathology
Volume86
Issue number2
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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