Murine Transfer Factors: Dose-Response Relationships and Routes of Administration

Charles H. Kirkpatrick, Abdel R Hamad, Lori C. Morton

Research output: Contribution to journalArticle

Abstract

Transfer factors are protein immunomodulators that transfer the ability to express cell-mediated immunity from immunized donors to nonimmune recipients. The effects are antigen-specific. The experiments described in this report are a comparison of the relationship of the route of administration of various transfer factors to the magnitude of the delayed hypersensitivity responses (footpad swelling) to the corresponding antigen in the recipients. Three doses of each of four affinity-purified transfer factor preparations were studied. There were no significant differences in the footpad responses by recipients of either oral or subcutaneous transfer factor. These results support proposals for oral administration of transfer factors in clinical trials.

Original languageEnglish (US)
Pages (from-to)203-206
Number of pages4
JournalCellular Immunology
Volume164
Issue number2
DOIs
StatePublished - Sep 1995
Externally publishedYes

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Transfer Factor
Antigens
Delayed Hypersensitivity
Immunologic Factors
Cellular Immunity
Oral Administration
Clinical Trials
Proteins

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Murine Transfer Factors : Dose-Response Relationships and Routes of Administration. / Kirkpatrick, Charles H.; Hamad, Abdel R; Morton, Lori C.

In: Cellular Immunology, Vol. 164, No. 2, 09.1995, p. 203-206.

Research output: Contribution to journalArticle

Kirkpatrick, Charles H. ; Hamad, Abdel R ; Morton, Lori C. / Murine Transfer Factors : Dose-Response Relationships and Routes of Administration. In: Cellular Immunology. 1995 ; Vol. 164, No. 2. pp. 203-206.
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