Multiwalled nanotubes formed by catanionic mixtures of drug amphiphiles

Yi An Lin, Andrew G. Cheetham, Pengcheng Zhang, Yu Chuan Ou, Yuguo Li, Guanshu Liu, Daniel Hermida-Merino, Ian W. Hamley, Honggang Cui

Research output: Contribution to journalArticle

Abstract

Mixing of oppositely charged amphiphilic molecules (catanionic mixing) offers an attractive strategy to produce morphologies different from those formed by individual molecules. We report here on the use of catanionic mixing of anticancer drug amphiphiles to construct multiwalled nanotubes containing a fixed and high drug loading. We found that the molecular mixing ratio, the solvent composition, the overall drug concentrations, as well as the molecular design of the studied amphiphiles are all important experimental parameters contributing to the tubular morphology. We believe these results demonstrate the remarkable potential that anticancer drugs could offer to self-Assemble into discrete nanostructures and also provide important insight into the formation mechanism of nanotubes by catanionic mixtures. Our preliminary animal studies reveal that the CPT nanotubes show significantly prolonged retention time in the tumor site after intratumoral injection.

Original languageEnglish (US)
Pages (from-to)12690-12700
Number of pages11
JournalACS Nano
Volume8
Issue number12
DOIs
StatePublished - Dec 23 2014

Keywords

  • camptothecin
  • catanionic mixtures
  • drug
  • nanotubes
  • self-Assembly

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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  • Cite this

    Lin, Y. A., Cheetham, A. G., Zhang, P., Ou, Y. C., Li, Y., Liu, G., Hermida-Merino, D., Hamley, I. W., & Cui, H. (2014). Multiwalled nanotubes formed by catanionic mixtures of drug amphiphiles. ACS Nano, 8(12), 12690-12700. https://doi.org/10.1021/nn505688b