Multivoxel proton magnetic resonance spectroscopy in facioscapulohumeral muscular dystrophy

Doris G. Leung, Xin Wang, Peter B. Barker, John A. Carrino, Kathryn R. Wagner

Research output: Contribution to journalArticle

Abstract

Introduction: Facioscapulohumeral muscular dystrophy (FSHD) is a hereditary disorder that causes progressive muscle wasting. This study evaluates the use of proton magnetic resonance spectroscopy ( 1 H MRS) as a biomarker of muscle strength and function in FSHD. Methods: Thirty-six individuals with FSHD and 15 healthy controls underwent multivoxel 1 H MRS of a cross-section of the mid-thigh. Concentrations of creatine, intramyocellular and extramyocellular lipids, and trimethylamine (TMA)-containing compounds in skeletal muscle were calculated. Metabolite concentrations for individuals with FSHD were compared with those of controls. The relationship between metabolite concentrations and muscle strength was also examined. Results: The TMA/creatine (Cr) ratio in individuals with FSHD was reduced compared with controls. The TMA/Cr ratio in the hamstrings also showed a moderate linear correlation with muscle strength. Discussion: 1 H MRS offers a potential method of detecting early muscle pathology in FSHD prior to the development of fat infiltration. Muscle Nerve 57: 958–963, 2018.

Original languageEnglish (US)
Pages (from-to)958-963
Number of pages6
JournalMuscle and Nerve
Volume57
Issue number6
DOIs
StatePublished - Jun 2018

Keywords

  • biomarkers
  • facioscapulohumeral muscular dystrophy
  • magnetic resonance spectroscopy
  • metabolite quantification
  • skeletal muscle
  • trimethylamine

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Multivoxel proton magnetic resonance spectroscopy in facioscapulohumeral muscular dystrophy'. Together they form a unique fingerprint.

Cite this