Multivoxel proton magnetic resonance spectroscopy in facioscapulohumeral muscular dystrophy

Doris G. Leung, Xin Wang, Peter B Barker, John A. Carrino, Kathryn Rae Wagner

Research output: Contribution to journalArticle

Abstract

Introduction: Facioscapulohumeral muscular dystrophy (FSHD) is a hereditary disorder that causes progressive muscle wasting. This study evaluates the use of proton magnetic resonance spectroscopy (1H MRS) as a biomarker of muscle strength and function in FSHD. Methods: Thirty-six individuals with FSHD and 15 healthy controls underwent multivoxel 1H MRS of a cross-section of the mid-thigh. Concentrations of creatine, intramyocellular and extramyocellular lipids, and trimethylamine (TMA)-containing compounds in skeletal muscle were calculated. Metabolite concentrations for individuals with FSHD were compared with those of controls. The relationship between metabolite concentrations and muscle strength was also examined. Results: The TMA/creatine (Cr) ratio in individuals with FSHD was reduced compared with controls. The TMA/Cr ratio in the hamstrings also showed a moderate linear correlation with muscle strength. Discussion: 1H MRS offers a potential method of detecting early muscle pathology in FSHD prior to the development of fat infiltration. Muscle Nerve 57: 958–963, 2018.

Original languageEnglish (US)
Pages (from-to)958-963
Number of pages6
JournalMuscle and Nerve
Volume57
Issue number6
DOIs
StatePublished - Jun 1 2018

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Facioscapulohumeral Muscular Dystrophy
Creatine
Muscle Strength
Muscles
Thigh
Proton Magnetic Resonance Spectroscopy
Skeletal Muscle
Biomarkers
Fats
Pathology
Lipids

Keywords

  • biomarkers
  • facioscapulohumeral muscular dystrophy
  • magnetic resonance spectroscopy
  • metabolite quantification
  • skeletal muscle
  • trimethylamine

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Multivoxel proton magnetic resonance spectroscopy in facioscapulohumeral muscular dystrophy. / Leung, Doris G.; Wang, Xin; Barker, Peter B; Carrino, John A.; Wagner, Kathryn Rae.

In: Muscle and Nerve, Vol. 57, No. 6, 01.06.2018, p. 958-963.

Research output: Contribution to journalArticle

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