Multivariate analysis of subjective responses to d-amphetamine in healthy volunteers finds novel genetic pathway associations

Haley L. Yarosh, Shashwath A. Meda, Harriet De Wit, Amy B. Hart, Godfrey D. Pearlson

Research output: Contribution to journalArticle

Abstract

Rationale: Researchers studying behavioral and physiologic effects of d-amphetamine have explored individual response differences to the drug. Concurrently, genome-wide analyses have identified several single-nucleotide polymorphisms (SNPs) associated with these traits. Univariate methods can identify SNPs associated with behavioral and physiological traits, but multivariate analyses allow identification of clusters of related biologically relevant SNPs and behavioral components. Objectives: The aim of the study was to identify clusters of related biologically relevant SNPs and behavioral components in the responses of healthy individuals to d-amphetamine using multivariate analysis. Methods: Individuals (N∈=∈375) without substance abuse histories completed surveys and detailed cardiovascular monitoring during randomized, blinded sessions: d-amphetamine (10 and 20 mg) and placebo. We applied parallel independent component analysis (Para-ICA) to data previously analyzed with univariate approaches, revealing new associations between genes and behavioral responses to d-amphetamine. Results: Three significantly associated (p∈

Original languageEnglish (US)
Pages (from-to)2781-2794
Number of pages14
JournalPsychopharmacology
Volume232
Issue number15
DOIs
StatePublished - Apr 7 2015
Externally publishedYes

Fingerprint

Dextroamphetamine
Single Nucleotide Polymorphism
Healthy Volunteers
Multivariate Analysis
Individuality
Substance-Related Disorders
Placebos
Research Personnel
Genome
Pharmaceutical Preparations
Genes

Keywords

  • Acute behavior
  • D-amphetamine
  • Parallel independent component analysis
  • Single-nucleotide polymorphism

ASJC Scopus subject areas

  • Pharmacology

Cite this

Multivariate analysis of subjective responses to d-amphetamine in healthy volunteers finds novel genetic pathway associations. / Yarosh, Haley L.; Meda, Shashwath A.; De Wit, Harriet; Hart, Amy B.; Pearlson, Godfrey D.

In: Psychopharmacology, Vol. 232, No. 15, 07.04.2015, p. 2781-2794.

Research output: Contribution to journalArticle

Yarosh, Haley L. ; Meda, Shashwath A. ; De Wit, Harriet ; Hart, Amy B. ; Pearlson, Godfrey D. / Multivariate analysis of subjective responses to d-amphetamine in healthy volunteers finds novel genetic pathway associations. In: Psychopharmacology. 2015 ; Vol. 232, No. 15. pp. 2781-2794.
@article{f3e0877f02c54aeb84a613a0aa0bd47c,
title = "Multivariate analysis of subjective responses to d-amphetamine in healthy volunteers finds novel genetic pathway associations",
abstract = "Rationale: Researchers studying behavioral and physiologic effects of d-amphetamine have explored individual response differences to the drug. Concurrently, genome-wide analyses have identified several single-nucleotide polymorphisms (SNPs) associated with these traits. Univariate methods can identify SNPs associated with behavioral and physiological traits, but multivariate analyses allow identification of clusters of related biologically relevant SNPs and behavioral components. Objectives: The aim of the study was to identify clusters of related biologically relevant SNPs and behavioral components in the responses of healthy individuals to d-amphetamine using multivariate analysis. Methods: Individuals (N∈=∈375) without substance abuse histories completed surveys and detailed cardiovascular monitoring during randomized, blinded sessions: d-amphetamine (10 and 20 mg) and placebo. We applied parallel independent component analysis (Para-ICA) to data previously analyzed with univariate approaches, revealing new associations between genes and behavioral responses to d-amphetamine. Results: Three significantly associated (p∈",
keywords = "Acute behavior, D-amphetamine, Parallel independent component analysis, Single-nucleotide polymorphism",
author = "Yarosh, {Haley L.} and Meda, {Shashwath A.} and {De Wit}, Harriet and Hart, {Amy B.} and Pearlson, {Godfrey D.}",
year = "2015",
month = "4",
day = "7",
doi = "10.1007/s00213-015-3914-1",
language = "English (US)",
volume = "232",
pages = "2781--2794",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "15",

}

TY - JOUR

T1 - Multivariate analysis of subjective responses to d-amphetamine in healthy volunteers finds novel genetic pathway associations

AU - Yarosh, Haley L.

AU - Meda, Shashwath A.

AU - De Wit, Harriet

AU - Hart, Amy B.

AU - Pearlson, Godfrey D.

PY - 2015/4/7

Y1 - 2015/4/7

N2 - Rationale: Researchers studying behavioral and physiologic effects of d-amphetamine have explored individual response differences to the drug. Concurrently, genome-wide analyses have identified several single-nucleotide polymorphisms (SNPs) associated with these traits. Univariate methods can identify SNPs associated with behavioral and physiological traits, but multivariate analyses allow identification of clusters of related biologically relevant SNPs and behavioral components. Objectives: The aim of the study was to identify clusters of related biologically relevant SNPs and behavioral components in the responses of healthy individuals to d-amphetamine using multivariate analysis. Methods: Individuals (N∈=∈375) without substance abuse histories completed surveys and detailed cardiovascular monitoring during randomized, blinded sessions: d-amphetamine (10 and 20 mg) and placebo. We applied parallel independent component analysis (Para-ICA) to data previously analyzed with univariate approaches, revealing new associations between genes and behavioral responses to d-amphetamine. Results: Three significantly associated (p∈

AB - Rationale: Researchers studying behavioral and physiologic effects of d-amphetamine have explored individual response differences to the drug. Concurrently, genome-wide analyses have identified several single-nucleotide polymorphisms (SNPs) associated with these traits. Univariate methods can identify SNPs associated with behavioral and physiological traits, but multivariate analyses allow identification of clusters of related biologically relevant SNPs and behavioral components. Objectives: The aim of the study was to identify clusters of related biologically relevant SNPs and behavioral components in the responses of healthy individuals to d-amphetamine using multivariate analysis. Methods: Individuals (N∈=∈375) without substance abuse histories completed surveys and detailed cardiovascular monitoring during randomized, blinded sessions: d-amphetamine (10 and 20 mg) and placebo. We applied parallel independent component analysis (Para-ICA) to data previously analyzed with univariate approaches, revealing new associations between genes and behavioral responses to d-amphetamine. Results: Three significantly associated (p∈

KW - Acute behavior

KW - D-amphetamine

KW - Parallel independent component analysis

KW - Single-nucleotide polymorphism

UR - http://www.scopus.com/inward/record.url?scp=84937736033&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937736033&partnerID=8YFLogxK

U2 - 10.1007/s00213-015-3914-1

DO - 10.1007/s00213-015-3914-1

M3 - Article

C2 - 25843748

AN - SCOPUS:84937736033

VL - 232

SP - 2781

EP - 2794

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 15

ER -