Multivariate analysis of risk factors in cadaver donor kidney transplantation

Fred Sanfilippo, William K. Vaughn, William M. Lefor, Everett K. Spees

Research output: Contribution to journalArticle

Abstract

Data collected prospectively on 3811 kidney transplants performed between June 1977 and July 1982 with follow-up to July 1984 by the 42 member institutions of the South-Eastern Organ Procurement foundation were analyzed to identify factors associated with graft and patient outcome in patents not receiving cyclosorine. Multivariate Cox regression analysis was used to examine the assocaiton and relative risk of 24 variables with three acturarial outcomes: overall graft failure, irreversible rejection, and patient death. Factors having no suggested association with any outcome included: recipient sex, hisory of pregnancy, blood group, and time on dialyis; organ preservation method, time and source; donor race; crossmatch test sensitivity; and annual center transplant rate. In decreasing order of relative risk, the factors most significantly associated with irreversible rejection were: loss of two or more prior grafts, low HLA-A, B match, lack of pretransplant blood transfusion, high (

Original languageEnglish (US)
Pages (from-to)28-34
Number of pages7
JournalTransplantation
Volume42
Issue number1
StatePublished - 1986
Externally publishedYes

Fingerprint

Cadaver
Kidney Transplantation
Multivariate Analysis
Tissue Donors
Transplants
Organ Preservation
Tissue and Organ Procurement
HLA-A Antigens
HLA-B Antigens
Patents
Blood Group Antigens
Blood Transfusion
Regression Analysis
Kidney
Pregnancy

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Sanfilippo, F., Vaughn, W. K., Lefor, W. M., & Spees, E. K. (1986). Multivariate analysis of risk factors in cadaver donor kidney transplantation. Transplantation, 42(1), 28-34.

Multivariate analysis of risk factors in cadaver donor kidney transplantation. / Sanfilippo, Fred; Vaughn, William K.; Lefor, William M.; Spees, Everett K.

In: Transplantation, Vol. 42, No. 1, 1986, p. 28-34.

Research output: Contribution to journalArticle

Sanfilippo, F, Vaughn, WK, Lefor, WM & Spees, EK 1986, 'Multivariate analysis of risk factors in cadaver donor kidney transplantation', Transplantation, vol. 42, no. 1, pp. 28-34.
Sanfilippo F, Vaughn WK, Lefor WM, Spees EK. Multivariate analysis of risk factors in cadaver donor kidney transplantation. Transplantation. 1986;42(1):28-34.
Sanfilippo, Fred ; Vaughn, William K. ; Lefor, William M. ; Spees, Everett K. / Multivariate analysis of risk factors in cadaver donor kidney transplantation. In: Transplantation. 1986 ; Vol. 42, No. 1. pp. 28-34.
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