Cell polarization is the process by which cells establish asymmetry along a single axis and is essential for processes such as cell migration and asymmetric cell division . Budding yeast is an excellent model for the study of cell polarity, because it divides asymmetrically between the mother and bud and displays a characteristic cell and actin morphology at each cell cycle stage, facilitating the study of different polarity states . Also, many proteins involved in cell polarity, such as the Rho GTPase Cdc42, are conserved from yeast to mammals , , . Yeast cells are round and unpolarized in G1 phase, but after the G1-S transition, the actin cytoskeleton and localization of the Cdc42 GTPase are polarized to the presumptive bud site . The cell is then set up for bud emergence, which occurs shortly afterwards. Bud formation through polarized growth is required for successful cell division.
|Original language||English (US)|
|Title of host publication||Investigations in Yeast Functional Genomics and Molecular Biology|
|Publisher||Apple Academic Press|
|Number of pages||28|
|Publication status||Published - Jan 1 2014|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)