Multisite phosphorylation of the guanine nucleotide exchange factor cdc24 during yeast cell polarization

Stephanie C. Wai, Scott A. Gerber, Rong Li

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cell polarization is the process by which cells establish asymmetry along a single axis and is essential for processes such as cell migration and asymmetric cell division [1]. Budding yeast is an excellent model for the study of cell polarity, because it divides asymmetrically between the mother and bud and displays a characteristic cell and actin morphology at each cell cycle stage, facilitating the study of different polarity states [2]. Also, many proteins involved in cell polarity, such as the Rho GTPase Cdc42, are conserved from yeast to mammals [3], [4], [5]. Yeast cells are round and unpolarized in G1 phase, but after the G1-S transition, the actin cytoskeleton and localization of the Cdc42 GTPase are polarized to the presumptive bud site [2]. The cell is then set up for bud emergence, which occurs shortly afterwards. Bud formation through polarized growth is required for successful cell division.

Original languageEnglish (US)
Title of host publicationInvestigations in Yeast Functional Genomics and Molecular Biology
PublisherApple Academic Press
Pages79-106
Number of pages28
ISBN (Electronic)9781482240962
ISBN (Print)9781771880107
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Multisite phosphorylation of the guanine nucleotide exchange factor cdc24 during yeast cell polarization'. Together they form a unique fingerprint.

Cite this