Multisensory convergence at human temporo-parietal junction - Epicortical recording of evoked responses

Masao Matsuhashi, Akio Ikeda, Shinji Ohara, Riki Matsumoto, Junichi Yamamoto, Motohiro Takayama, Takeshi Satow, Tahamina Begum, Keiko Usui, Takashi Nagamine, Nobuhiro Mikuni, Jun Takahashi, Susumu Miyamoto, Hidenao Fukuyama, Hiroshi Shibasaki

Research output: Contribution to journalArticle

Abstract

Objective: Previous lesion studies in patients and functional imaging studies in normal subjects have led to the notion that the temporo-parietal junction (TPJ) has an integrative function for multisensory inputs. However, its electrophysiological properties such as response latencies and distributions of responses to various stimulus modalities in humans have not been fully investigated. The aim of the study is to clarify this issue. Methods: We recorded evoked potentials to different kinds of sensory stimuli including somatosensory, auditory and visual modalities in 6 patients with intractable partial epilepsy, who underwent chronic implantation of subdural electrodes in TPJ for presurgical evaluation. Results: In 5 out of 6 subjects, at least one electrode located in TPJ for each subject showed a maximum somatosensory evoked response commonly to electric, passive joint motion and pain stimuli. These electrodes showed the maximum responses also to tone stimuli in all of 4 subjects studied, and to visual motion stimuli in 3 out of 5 subjects studied. The polarity was consistent regardless of the stimulus modality within each individual subject, although the anatomical location, polarity and latency varied among subjects. Conclusions: A small area in TPJ for each individual subject receives sensory information of multiple modalities possibly coming from different receptive sites, although the electrophysiological properties of the responses may vary among subjects. Significance: We confirmed the convergence of somatosensory, auditory and visual evoked responses at human TPJ.

Original languageEnglish (US)
Pages (from-to)1145-1160
Number of pages16
JournalClinical Neurophysiology
Volume115
Issue number5
DOIs
StatePublished - May 2004
Externally publishedYes

Keywords

  • Epicortical recording
  • Inferior parietal lobule
  • Multimodal sensory area
  • Multisensory integration
  • Somatosensory evoked potential
  • Temporo-parietal junction

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Sensory Systems
  • Physiology (medical)

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  • Cite this

    Matsuhashi, M., Ikeda, A., Ohara, S., Matsumoto, R., Yamamoto, J., Takayama, M., Satow, T., Begum, T., Usui, K., Nagamine, T., Mikuni, N., Takahashi, J., Miyamoto, S., Fukuyama, H., & Shibasaki, H. (2004). Multisensory convergence at human temporo-parietal junction - Epicortical recording of evoked responses. Clinical Neurophysiology, 115(5), 1145-1160. https://doi.org/10.1016/j.clinph.2003.12.009