TY - JOUR
T1 - Multisensory convergence at human temporo-parietal junction - Epicortical recording of evoked responses
AU - Matsuhashi, Masao
AU - Ikeda, Akio
AU - Ohara, Shinji
AU - Matsumoto, Riki
AU - Yamamoto, Junichi
AU - Takayama, Motohiro
AU - Satow, Takeshi
AU - Begum, Tahamina
AU - Usui, Keiko
AU - Nagamine, Takashi
AU - Mikuni, Nobuhiro
AU - Takahashi, Jun
AU - Miyamoto, Susumu
AU - Fukuyama, Hidenao
AU - Shibasaki, Hiroshi
PY - 2004/5
Y1 - 2004/5
N2 - Objective: Previous lesion studies in patients and functional imaging studies in normal subjects have led to the notion that the temporo-parietal junction (TPJ) has an integrative function for multisensory inputs. However, its electrophysiological properties such as response latencies and distributions of responses to various stimulus modalities in humans have not been fully investigated. The aim of the study is to clarify this issue. Methods: We recorded evoked potentials to different kinds of sensory stimuli including somatosensory, auditory and visual modalities in 6 patients with intractable partial epilepsy, who underwent chronic implantation of subdural electrodes in TPJ for presurgical evaluation. Results: In 5 out of 6 subjects, at least one electrode located in TPJ for each subject showed a maximum somatosensory evoked response commonly to electric, passive joint motion and pain stimuli. These electrodes showed the maximum responses also to tone stimuli in all of 4 subjects studied, and to visual motion stimuli in 3 out of 5 subjects studied. The polarity was consistent regardless of the stimulus modality within each individual subject, although the anatomical location, polarity and latency varied among subjects. Conclusions: A small area in TPJ for each individual subject receives sensory information of multiple modalities possibly coming from different receptive sites, although the electrophysiological properties of the responses may vary among subjects. Significance: We confirmed the convergence of somatosensory, auditory and visual evoked responses at human TPJ.
AB - Objective: Previous lesion studies in patients and functional imaging studies in normal subjects have led to the notion that the temporo-parietal junction (TPJ) has an integrative function for multisensory inputs. However, its electrophysiological properties such as response latencies and distributions of responses to various stimulus modalities in humans have not been fully investigated. The aim of the study is to clarify this issue. Methods: We recorded evoked potentials to different kinds of sensory stimuli including somatosensory, auditory and visual modalities in 6 patients with intractable partial epilepsy, who underwent chronic implantation of subdural electrodes in TPJ for presurgical evaluation. Results: In 5 out of 6 subjects, at least one electrode located in TPJ for each subject showed a maximum somatosensory evoked response commonly to electric, passive joint motion and pain stimuli. These electrodes showed the maximum responses also to tone stimuli in all of 4 subjects studied, and to visual motion stimuli in 3 out of 5 subjects studied. The polarity was consistent regardless of the stimulus modality within each individual subject, although the anatomical location, polarity and latency varied among subjects. Conclusions: A small area in TPJ for each individual subject receives sensory information of multiple modalities possibly coming from different receptive sites, although the electrophysiological properties of the responses may vary among subjects. Significance: We confirmed the convergence of somatosensory, auditory and visual evoked responses at human TPJ.
KW - Epicortical recording
KW - Inferior parietal lobule
KW - Multimodal sensory area
KW - Multisensory integration
KW - Somatosensory evoked potential
KW - Temporo-parietal junction
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U2 - 10.1016/j.clinph.2003.12.009
DO - 10.1016/j.clinph.2003.12.009
M3 - Article
C2 - 15066540
AN - SCOPUS:11144356751
SN - 1388-2457
VL - 115
SP - 1145
EP - 1160
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
IS - 5
ER -