TY - JOUR
T1 - Multiscale models of angiogenesis
AU - Qutub, Amina
AU - Gabhann, Feilim
AU - Karagiannis, Emmanouil
AU - Vempati, Prakash
AU - Popel, Aleksander
N1 - Funding Information:
This work was supported by NIH grants RO1 HL79653 and R33 HL087351, and NIH 1F32HL085016-01 (Amina A. Qutub). Feilim Mac Gabhann is currently supported by NIH training grant T32 HL7284. We thank James Ji, Carmen Kut, and Michael Yang for their contributions to this research, and Mikhail Basilyan for his work on software development. We also thank laboratory members Marianne Stefanini, Kejing Chen, David Noren, Jacob Koskimaki, and Florence Wu for numerous discussions and constructive suggestions, Florence Wu for drawing Figure 1, and Nikolaos Tsoukias for providing Figure 3.
PY - 2009/3
Y1 - 2009/3
N2 - Vascular disease, cancer, stroke, neurodegeneration, diabetes, inflammation, asthma, obesity, arthritis--the list of conditions that involve angiogenesis reads like main chapters in a book on pathology. Angiogenesis, the growth of capillaries from preexisting vessels, also occurs in normal physiology, in response to exercise or in the process of wound healing.Why and when is angiogenesis prevalent? What controls the process? How can we intelligently control it? These are the key questions driving researchers in fields as diverse as cell biology, oncology, cardiology, neurology, biomathematics, systems biology, and biomedical engineering. As bioengineers, we approach angiogenesis as a complex, interconnected system of events occurring in sequence and in parallel, on multiple levels, triggered by a main stimulus, e.g., hypoxia.
AB - Vascular disease, cancer, stroke, neurodegeneration, diabetes, inflammation, asthma, obesity, arthritis--the list of conditions that involve angiogenesis reads like main chapters in a book on pathology. Angiogenesis, the growth of capillaries from preexisting vessels, also occurs in normal physiology, in response to exercise or in the process of wound healing.Why and when is angiogenesis prevalent? What controls the process? How can we intelligently control it? These are the key questions driving researchers in fields as diverse as cell biology, oncology, cardiology, neurology, biomathematics, systems biology, and biomedical engineering. As bioengineers, we approach angiogenesis as a complex, interconnected system of events occurring in sequence and in parallel, on multiple levels, triggered by a main stimulus, e.g., hypoxia.
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U2 - 10.1109/MEMB.2009.931791
DO - 10.1109/MEMB.2009.931791
M3 - Article
C2 - 19349248
AN - SCOPUS:64349094583
SN - 0739-5175
VL - 28
SP - 14
EP - 31
JO - IEEE Engineering in Medicine and Biology Magazine
JF - IEEE Engineering in Medicine and Biology Magazine
IS - 2
M1 - 4809858
ER -