Multiscale models of angiogenesis

Amina Qutub, Feilim Gabhann, Emmanouil Karagiannis, Prakash Vempati, Aleksander Popel

Research output: Contribution to journalArticle

Abstract

Vascular disease, cancer, stroke, neurodegeneration, diabetes, inflammation, asthma, obesity, arthritis--the list of conditions that involve angiogenesis reads like main chapters in a book on pathology. Angiogenesis, the growth of capillaries from preexisting vessels, also occurs in normal physiology, in response to exercise or in the process of wound healing.Why and when is angiogenesis prevalent? What controls the process? How can we intelligently control it? These are the key questions driving researchers in fields as diverse as cell biology, oncology, cardiology, neurology, biomathematics, systems biology, and biomedical engineering. As bioengineers, we approach angiogenesis as a complex, interconnected system of events occurring in sequence and in parallel, on multiple levels, triggered by a main stimulus, e.g., hypoxia.

Original languageEnglish (US)
Article number4809858
Pages (from-to)14-31
Number of pages18
JournalIEEE Engineering in Medicine and Biology Magazine
Volume28
Issue number2
DOIs
StatePublished - Mar 1 2009

    Fingerprint

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Qutub, A., Gabhann, F., Karagiannis, E., Vempati, P., & Popel, A. (2009). Multiscale models of angiogenesis. IEEE Engineering in Medicine and Biology Magazine, 28(2), 14-31. [4809858]. https://doi.org/10.1109/MEMB.2009.931791