Multiscale deformable registration for dual-energy x-ray imaging

Jianan Gang, C. A. Varon, H. Kashani, S. Richard, N. S. Paul, R. Van Metter, J. Yorkston, Jeff Siewerdsen

Research output: Contribution to journalArticle

Abstract

Dual-energy (DE) imaging of the chest improves the conspicuity of subtle lung nodules through the removal of overlying anatomical noise. Recent work has shown double-shot DE imaging (i.e., successive acquisition of low- and high-energy projections) to provide detective quantum efficiency, spectral separation (and therefore contrast), and radiation dose superior to single-shot DE imaging configurations (e.g., with a CR cassette). However, the temporal separation between high-energy (HE) and low-energy (LE) image acquisition can result in motion artifacts in the DE images, reducing image quality and diminishing diagnostic performance. This has motivated the development of a deformable registration technique that aligns the HE image onto the LE image before DE decomposition. The algorithm reported here operates in multiple passes at progressively smaller scales and increasing resolution. The first pass addresses large-scale motion by means of mutual information optimization, while successive passes (2-4) correct misregistration at finer scales by means of normalized cross correlation. Evaluation of registration performance in 129 patients imaged using an experimental DE imaging prototype demonstrated a statistically significant improvement in image alignment. Specific to the cardiac region, the registration algorithm was found to outperform a simple cardiac-gating system designed to trigger both HE and LE exposures during diastole. Modulation transfer function (MTF) analysis reveals additional advantages in DE image quality in terms of noise reduction and edge enhancement. This algorithm could offer an important tool in enhancing DE image quality and potentially improving diagnostic performance.

Original languageEnglish (US)
Pages (from-to)351-363
Number of pages13
JournalMedical Physics
Volume36
Issue number2
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

X-Rays
Noise
Diastole
Artifacts
Thorax
Radiation
Lung

Keywords

  • Deformable registration
  • Dual-energy imaging
  • Flat-panel detector
  • Image registration
  • Morphological pyramid
  • Multiscale registration
  • Mutual information
  • Normalized cross correlation

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

Gang, J., Varon, C. A., Kashani, H., Richard, S., Paul, N. S., Van Metter, R., ... Siewerdsen, J. (2009). Multiscale deformable registration for dual-energy x-ray imaging. Medical Physics, 36(2), 351-363. https://doi.org/10.1118/1.3036981

Multiscale deformable registration for dual-energy x-ray imaging. / Gang, Jianan; Varon, C. A.; Kashani, H.; Richard, S.; Paul, N. S.; Van Metter, R.; Yorkston, J.; Siewerdsen, Jeff.

In: Medical Physics, Vol. 36, No. 2, 2009, p. 351-363.

Research output: Contribution to journalArticle

Gang, J, Varon, CA, Kashani, H, Richard, S, Paul, NS, Van Metter, R, Yorkston, J & Siewerdsen, J 2009, 'Multiscale deformable registration for dual-energy x-ray imaging', Medical Physics, vol. 36, no. 2, pp. 351-363. https://doi.org/10.1118/1.3036981
Gang J, Varon CA, Kashani H, Richard S, Paul NS, Van Metter R et al. Multiscale deformable registration for dual-energy x-ray imaging. Medical Physics. 2009;36(2):351-363. https://doi.org/10.1118/1.3036981
Gang, Jianan ; Varon, C. A. ; Kashani, H. ; Richard, S. ; Paul, N. S. ; Van Metter, R. ; Yorkston, J. ; Siewerdsen, Jeff. / Multiscale deformable registration for dual-energy x-ray imaging. In: Medical Physics. 2009 ; Vol. 36, No. 2. pp. 351-363.
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