Multiresolution entropy measure for neuronal multiunit activity

Young Seok Choi, Matthew A. Koenig, Xiaofeng Jia, Nitish V. Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

It is known that the multiunit activity (MUA) reflects the status of population of neurons in the vicinity of an electrode. We provide a quantitative measure of the time-varying multiunit neuronal spiking activity using an entropy based approach. To verify the status embedded in the neuronal activity of a population of neurons, we incorporate the discrete wavelet transform (DWT) to isolate the inherent spiking activity of MUA from the noise and background cortical activity or field potentials. Owing to the decorrelating property of DWT, the spiking activity would be preserved while reducing the non-spiking component such as the background noise. By evaluating the entropy of the wavelet coefficients of the denoised MUA, a multiresolution entropy of the MUA signal is developed. The proposed entropy measure was tested in the analysis of both simulated noisy MUA and actual MUA recorded from cortex in rodent model which undergoes hypoxic-ischemic brain injury. Simulation and Experimental results demonstrate that the dynamics of a population can be quantified by using the proposed multiresolution entropy.

Original languageEnglish (US)
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Subtitle of host publicationEngineering the Future of Biomedicine, EMBC 2009
PublisherIEEE Computer Society
Pages4715-4718
Number of pages4
ISBN (Print)9781424432967
DOIs
StatePublished - 2009
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Publication series

NameProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period9/2/099/6/09

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

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