Abstract
Transcription in eukaryotes is frequently regulated by a mechanism termed combinatorial control, whereby several different proteins must bind DNA in concert to achieve appropriate regulation of the downstream gene. X- ray crystallographic studies of multiprotein complexes bound to DNA have been carried out to investigate the molecular determinants of complex assembly and DNA binding. This work has provided important insights into the specific protein-protein and protein-DNA interactions that govern the assembly of multiprotein regulatory complexes. The results of these studies are reviewed here, and the general insights into the mechanism of combinatorial gene regulation are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 29-56 |
| Number of pages | 28 |
| Journal | Annual Review of Biophysics and Biomolecular Structure |
| Volume | 28 |
| DOIs | |
| State | Published - Jan 1 1999 |
Keywords
- Combinatorial control
- Crystal structure
- Gene regulation
- Protein-DNA interactions
- Transcription
ASJC Scopus subject areas
- Biophysics
- Structural Biology