Multipoint mapping studies of six loci on chromosome 11

Deborah A. Meyers, T. H. Beaty, N. E. Maestri, S. D. Kittur, S. E. Antonarakis, H. H. Kazazian

Research output: Contribution to journalArticlepeer-review

Abstract

The six loci, β-globin (HBBC), parathyroid hormone (PTH), oncogene c-Ha-ras-1 (HRAS1), insulin (INS), calcitonin (CAL) and catalase (CAT) loci, have been mapped to 1 lp in the order: CAT-CAL-PTH-HBBC-(HRASl-INS). The purpose of the current study was to examine the linkage relationships, especially the multipoint relationships of these loci in detail. In the 18 families studied, a significant sex difference in recombination was found for the HBBC: HRAS1 linkage with more recombination in the male parent than the female parent (22 vs. 2%). The results of the multipoint analyses provided further evidence for the order CAT-CAL-PTH-HBBC-(HRASl-INS); however, the order of the last two tightly linked loci is still not clear.

Original languageEnglish (US)
Pages (from-to)94-101
Number of pages8
JournalHuman Heredity
Volume37
Issue number2
DOIs
StatePublished - Jan 1 1987

Keywords

  • 11p
  • CAL
  • CAT
  • Chromosome 11
  • HBBC
  • HRAS1
  • INS
  • Linkage
  • Multipoint mapping
  • PTH

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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