Multipoint linkage analysis under heterogeneity: Incorporation of parametric and nonparametric approaches

Y. F. Chiu, A. M. Addington, Terri L Beaty, Alison Klein, K. Y. Liang

Research output: Contribution to journalArticle

Abstract

Using a recently developed multipoint parametric method, which tests for linkage in the presence of heterogeneity, we performed a genome-wide search for linkage using the German asthma data. Both dominant and recessive models were assumed in this parametric approach. Identity-by-descent (IBD) sharing for affected sibs was also calculated to help identify an appropriate genetic model and localize the trait locus. The strongest evidence for linkage was on chromosome 6 (p-value=0.00006) under the dominant model with heterogeneity. Using both linkage and IBD sharing information for D6S422 (36.55 cM) on chromosome 6, we conducted exploratory analyses to locate additional trait loci that might explain the linkage heterogeneity. We found evidence of heterogeneity between D6S422 and D11S4111 based on a test of association (p-value = 0.0015).

Original languageEnglish (US)
JournalGenetic Epidemiology
Volume21
Issue numberSUPPL. 1
StatePublished - 2001
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 6
Information Dissemination
Genetic Models
Asthma
Genome

Keywords

  • Admixture model
  • Genetic linkage
  • IBD sharing
  • Locus heterogeneity

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

Cite this

Multipoint linkage analysis under heterogeneity : Incorporation of parametric and nonparametric approaches. / Chiu, Y. F.; Addington, A. M.; Beaty, Terri L; Klein, Alison; Liang, K. Y.

In: Genetic Epidemiology, Vol. 21, No. SUPPL. 1, 2001.

Research output: Contribution to journalArticle

@article{1335f0f44375431bb7f3e10fdc83cd71,
title = "Multipoint linkage analysis under heterogeneity: Incorporation of parametric and nonparametric approaches",
abstract = "Using a recently developed multipoint parametric method, which tests for linkage in the presence of heterogeneity, we performed a genome-wide search for linkage using the German asthma data. Both dominant and recessive models were assumed in this parametric approach. Identity-by-descent (IBD) sharing for affected sibs was also calculated to help identify an appropriate genetic model and localize the trait locus. The strongest evidence for linkage was on chromosome 6 (p-value=0.00006) under the dominant model with heterogeneity. Using both linkage and IBD sharing information for D6S422 (36.55 cM) on chromosome 6, we conducted exploratory analyses to locate additional trait loci that might explain the linkage heterogeneity. We found evidence of heterogeneity between D6S422 and D11S4111 based on a test of association (p-value = 0.0015).",
keywords = "Admixture model, Genetic linkage, IBD sharing, Locus heterogeneity",
author = "Chiu, {Y. F.} and Addington, {A. M.} and Beaty, {Terri L} and Alison Klein and Liang, {K. Y.}",
year = "2001",
language = "English (US)",
volume = "21",
journal = "Genetic Epidemiology",
issn = "0741-0395",
publisher = "Wiley-Liss Inc.",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Multipoint linkage analysis under heterogeneity

T2 - Incorporation of parametric and nonparametric approaches

AU - Chiu, Y. F.

AU - Addington, A. M.

AU - Beaty, Terri L

AU - Klein, Alison

AU - Liang, K. Y.

PY - 2001

Y1 - 2001

N2 - Using a recently developed multipoint parametric method, which tests for linkage in the presence of heterogeneity, we performed a genome-wide search for linkage using the German asthma data. Both dominant and recessive models were assumed in this parametric approach. Identity-by-descent (IBD) sharing for affected sibs was also calculated to help identify an appropriate genetic model and localize the trait locus. The strongest evidence for linkage was on chromosome 6 (p-value=0.00006) under the dominant model with heterogeneity. Using both linkage and IBD sharing information for D6S422 (36.55 cM) on chromosome 6, we conducted exploratory analyses to locate additional trait loci that might explain the linkage heterogeneity. We found evidence of heterogeneity between D6S422 and D11S4111 based on a test of association (p-value = 0.0015).

AB - Using a recently developed multipoint parametric method, which tests for linkage in the presence of heterogeneity, we performed a genome-wide search for linkage using the German asthma data. Both dominant and recessive models were assumed in this parametric approach. Identity-by-descent (IBD) sharing for affected sibs was also calculated to help identify an appropriate genetic model and localize the trait locus. The strongest evidence for linkage was on chromosome 6 (p-value=0.00006) under the dominant model with heterogeneity. Using both linkage and IBD sharing information for D6S422 (36.55 cM) on chromosome 6, we conducted exploratory analyses to locate additional trait loci that might explain the linkage heterogeneity. We found evidence of heterogeneity between D6S422 and D11S4111 based on a test of association (p-value = 0.0015).

KW - Admixture model

KW - Genetic linkage

KW - IBD sharing

KW - Locus heterogeneity

UR - http://www.scopus.com/inward/record.url?scp=0034787651&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034787651&partnerID=8YFLogxK

M3 - Article

C2 - 11793735

AN - SCOPUS:0034787651

VL - 21

JO - Genetic Epidemiology

JF - Genetic Epidemiology

SN - 0741-0395

IS - SUPPL. 1

ER -