Multiplicity of BMP signaling in skeletal development

Xiangwei Wu, Weibin Shi, Xu Cao

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Skeletal development and homeostasis are complex processes involving systemic regulatory factors and local factors present in the bone microenvironment. Among these factors, bone morphogenetic proteins (BMPs) represent the major potent bone morphogens, which coordinate with other factors to exert their multiple functions by regulating cell condensation, as well as inducing chondrogenesis and osteogenesis. This article reviews the current status of BMP signaling in skeletal development, with focus on regulation at the level of the receptors. Crosstalk of the BMP pathway with other major signaling pathways is also summarized.

Original languageEnglish (US)
Title of host publicationSkeletal Biology and Medicine, Part A
Subtitle of host publicationAspects of Bone Morphogenesis and Remodeling
PublisherBlackwell Publishing Inc.
Number of pages21
ISBN (Print)9781573316842
StatePublished - Nov 2007
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • Bone morphogenetic protein
  • Chondrocyte
  • Osteoblast
  • Skeletogenesis
  • Transforming growth factor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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