Multiple Tumor Suppressor Genes in Multistep Carcinogenesis

Andrew P. Feinberg; Laura A. Johnson; J. David; Bryan R.G. Williams; Gilles Thomas; C. Richard Boland

doi:10.1620/tjem.168.149

Multiple Tumor Suppressor Genes in Multistep Carcinogenesis

Andrew P. Feinberg, Laura A. Johnson, J. David, Bryan R.G. Williams, Gilles Thomas, C. Richard Boland

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

One of the most exciting areas of molecular oncology is the convergence of two independent lines of evidence suggesting involvement of multiple tumor suppressor genes in a given type of cancer. First, epidemiology and somatic cell genetics indicate the presence of multiple tumor suppressor genes in each of several malignancies. Second, cancers often lose multiple chromosomal regions during tumor progression. We will use two tumors, colorectal cancer and Wilms tumor, to illustrate the questions that multiple tumor suppressor genes raise.

Original language	English (US)
Pages (from-to)	149-152
Number of pages	4
Journal	Tohoku Journal of Experimental Medicine
Volume	168
Issue number	2
DOIs	https://doi.org/10.1620/tjem.168.149
State	Published - 1992
Externally published	Yes

Keywords

DNA methylation
Wilms tumor (WT)
allelic loss of chromosome
multistep carcinogenesis
tumor suppressor genes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1620/tjem.168.149

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keywords = "DNA methylation, Wilms tumor (WT), allelic loss of chromosome, multistep carcinogenesis, tumor suppressor genes",

author = "Feinberg, {Andrew P.} and Johnson, {Laura A.} and J. David and Williams, {Bryan R.G.} and Gilles Thomas and Boland, {C. Richard}",

year = "1992",

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volume = "168",

pages = "149--152",

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AU - Feinberg, Andrew P.

AU - Johnson, Laura A.

AU - David, J.

AU - Williams, Bryan R.G.

AU - Thomas, Gilles

AU - Boland, C. Richard

PY - 1992

Y1 - 1992

N2 - One of the most exciting areas of molecular oncology is the convergence of two independent lines of evidence suggesting involvement of multiple tumor suppressor genes in a given type of cancer. First, epidemiology and somatic cell genetics indicate the presence of multiple tumor suppressor genes in each of several malignancies. Second, cancers often lose multiple chromosomal regions during tumor progression. We will use two tumors, colorectal cancer and Wilms tumor, to illustrate the questions that multiple tumor suppressor genes raise.

AB - One of the most exciting areas of molecular oncology is the convergence of two independent lines of evidence suggesting involvement of multiple tumor suppressor genes in a given type of cancer. First, epidemiology and somatic cell genetics indicate the presence of multiple tumor suppressor genes in each of several malignancies. Second, cancers often lose multiple chromosomal regions during tumor progression. We will use two tumors, colorectal cancer and Wilms tumor, to illustrate the questions that multiple tumor suppressor genes raise.

KW - DNA methylation

KW - Wilms tumor (WT)

KW - allelic loss of chromosome

KW - multistep carcinogenesis

KW - tumor suppressor genes

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JO - Tohoku Journal of Experimental Medicine

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ER -

Multiple Tumor Suppressor Genes in Multistep Carcinogenesis

Abstract

Keywords

ASJC Scopus subject areas

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