Multiple [3H]imipramine binding sites in brains of male and female Fawn-Hooded and Long-Evans rats

John R. Ieni, Ethel Tobach, Stephen R. Zukin, Gordon A. Barr, Herman M. Van Praag

Research output: Contribution to journalArticlepeer-review

Abstract

Comparisons of high- and low-affinity [3H]imipramine binding to whole brain homogenates from adult male and female rats of the Fawn-Hooded and Long-Evans strains were performed. Most strikingly, no significant differences were observed between the two strains in any of the binding parameters, indicating that brain [3H]imipramine binding sites, which may be related to the serotonergic uptake process, appear normal in a strain of rats with serotonin platelet storage pool disease. However, a signficant sex difference in high- but not low-affinity whole brain [3H]imipramine Bmax values was observed, with females of both strains having higher densities than males. The observed sex difference in densities of high-affinity [3H]imipramine binding sites necessitates further research into possible sex hormone interactions with this binding site and serotonergic transmitter systems.

Original languageEnglish (US)
Pages (from-to)261-264
Number of pages4
JournalEuropean Journal of Pharmacology
Volume112
Issue number2
DOIs
StatePublished - Jun 7 1985
Externally publishedYes

Keywords

  • Fawn-Hooded rats
  • High affinity
  • Low affinity
  • Sex differences
  • [H]Imipramine binding

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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