Multiple sclerosis exceptionally presenting as parkinsonism responds to intravenous methylprednisolone

S. Saidha, T. H. Mok, M. Butler, N. Fanning, H. Harrington

Research output: Contribution to journalArticlepeer-review


Parkinsonism due to multiple sclerosis (MS) is rare. In previously reported patients with MS-induced parkinsonism, MS manifested first, followed a typical clinical course, and parkinsonism developed later in the course of the illness. We report a 52-year-old male presenting with parkinsonism as the initial manifestation of MS, in whom a subsequent MS relapse consisted of marked deterioration in parkinsonism, a clinical pattern not previously described in MS. A brain MRI demonstrated involvement of the substantia nigra and basal ganglia. This patient illustrates that the clinical presentation and progression of MS may rarely be characterised by predominating parkinsonian features which are reversible by treatment with intravenous methylprednisolone and interferon β1a.

Original languageEnglish (US)
Pages (from-to)654-655
Number of pages2
JournalJournal of Clinical Neuroscience
Issue number5
StatePublished - May 1 2010
Externally publishedYes


  • Interferon β1a
  • Intravenous methylprednisolone
  • MRI
  • Multiple sclerosis
  • Parkinsonism

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)


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