Multiple reassortment events among highly pathogenic avian influenza A(H5N1) viruses detected in Bangladesh

Nancy A. Gerloff, Salah Uddin Khan, Amanda Balish, Ireen S. Shanta, Natosha Simpson, La Shondra Berman, Najmul Haider, Mee Kian Poh, Ausraful Islam, Emily Gurley, Md Abdul Hasnat, T. Dey, Bo Shu, Shannon Emery, Stephen Lindstrom, Ainul Haque, Alexander Klimov, Julie Villanueva, Mahmudur Rahman, Eduardo Azziz-BaumgartnerMd Ziaur Rahman, Stephen P. Luby, Nord Zeidner, Ruben O. Donis, Katharine Sturm-Ramirez, C. Todd Davis

Research output: Contribution to journalArticle

Abstract

In Bangladesh, little is known about the genomic composition and antigenicity of highly pathogenic avian influenza A(H5N1) viruses, their geographic distribution, temporal patterns, or gene flow within the avian host population. Forty highly pathogenic avian influenza A(H5N1) viruses isolated from humans and poultry in Bangladesh between 2008 and 2012 were analyzed by full genome sequencing and antigenic characterization. The analysis included viruses collected from avian hosts and environmental sampling in live bird markets, backyard poultry flocks, outbreak investigations in wild birds or poultry and from three human cases. Phylogenetic analysis indicated that the ancestors of these viruses reassorted (1) with other gene lineages of the same clade, (2) between different clades and (3) with low pathogenicity avian influenza A virus subtypes. Bayesian estimates of the time of most recent common ancestry, combined with geographic information, provided evidence of probable routes and timelines of virus spread into and out of Bangladesh.

Original languageEnglish (US)
Pages (from-to)297-307
Number of pages11
JournalVirology
Volume450-451
DOIs
StatePublished - Feb 1 2014
Externally publishedYes

Fingerprint

H5N1 Subtype Influenza A Virus
Influenza in Birds
Bangladesh
Influenza A virus
Poultry
Viruses
Birds
Gene Flow
Disease Outbreaks
Virulence
Genome
Population
Genes

Keywords

  • Antigenicity
  • Avian influenza
  • Bangladesh
  • Evolution
  • Orthomyxovirus
  • Phylogenetics
  • Reassortment

ASJC Scopus subject areas

  • Virology

Cite this

Gerloff, N. A., Khan, S. U., Balish, A., Shanta, I. S., Simpson, N., Berman, L. S., ... Davis, C. T. (2014). Multiple reassortment events among highly pathogenic avian influenza A(H5N1) viruses detected in Bangladesh. Virology, 450-451, 297-307. https://doi.org/10.1016/j.virol.2013.12.023

Multiple reassortment events among highly pathogenic avian influenza A(H5N1) viruses detected in Bangladesh. / Gerloff, Nancy A.; Khan, Salah Uddin; Balish, Amanda; Shanta, Ireen S.; Simpson, Natosha; Berman, La Shondra; Haider, Najmul; Poh, Mee Kian; Islam, Ausraful; Gurley, Emily; Hasnat, Md Abdul; Dey, T.; Shu, Bo; Emery, Shannon; Lindstrom, Stephen; Haque, Ainul; Klimov, Alexander; Villanueva, Julie; Rahman, Mahmudur; Azziz-Baumgartner, Eduardo; Ziaur Rahman, Md; Luby, Stephen P.; Zeidner, Nord; Donis, Ruben O.; Sturm-Ramirez, Katharine; Davis, C. Todd.

In: Virology, Vol. 450-451, 01.02.2014, p. 297-307.

Research output: Contribution to journalArticle

Gerloff, NA, Khan, SU, Balish, A, Shanta, IS, Simpson, N, Berman, LS, Haider, N, Poh, MK, Islam, A, Gurley, E, Hasnat, MA, Dey, T, Shu, B, Emery, S, Lindstrom, S, Haque, A, Klimov, A, Villanueva, J, Rahman, M, Azziz-Baumgartner, E, Ziaur Rahman, M, Luby, SP, Zeidner, N, Donis, RO, Sturm-Ramirez, K & Davis, CT 2014, 'Multiple reassortment events among highly pathogenic avian influenza A(H5N1) viruses detected in Bangladesh', Virology, vol. 450-451, pp. 297-307. https://doi.org/10.1016/j.virol.2013.12.023
Gerloff, Nancy A. ; Khan, Salah Uddin ; Balish, Amanda ; Shanta, Ireen S. ; Simpson, Natosha ; Berman, La Shondra ; Haider, Najmul ; Poh, Mee Kian ; Islam, Ausraful ; Gurley, Emily ; Hasnat, Md Abdul ; Dey, T. ; Shu, Bo ; Emery, Shannon ; Lindstrom, Stephen ; Haque, Ainul ; Klimov, Alexander ; Villanueva, Julie ; Rahman, Mahmudur ; Azziz-Baumgartner, Eduardo ; Ziaur Rahman, Md ; Luby, Stephen P. ; Zeidner, Nord ; Donis, Ruben O. ; Sturm-Ramirez, Katharine ; Davis, C. Todd. / Multiple reassortment events among highly pathogenic avian influenza A(H5N1) viruses detected in Bangladesh. In: Virology. 2014 ; Vol. 450-451. pp. 297-307.
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