Multiple primary neoplasms in patients with salivary gland or thyroid gland tumors

Michael E. Johns, Alain H. Shikhani, Haskins K. Kashima, Genevieve Matanoski

Research output: Contribution to journalArticle

Abstract

The exact risk of multiple primary neoplasms in patients with salivary gland or thyroid gland malignancies is difficult to ascertain from the data available in the literature. This study examines, retrospectively, 198 patients with a first malignancy of the salivary gland and 186 patients with a first malignancy of the thyroid gland, treated over a 10-year period. Fourteen cases of second tumors were found in the first group and 29 cases in the latter. Patients whose second neoplasm was a skin cancer or who had a previous neoplasm at a site other than those selected for study were excluded. The risk of a second tumor was compared to the expected number of second cancers from the Combined National Cancer Institute Registry Data, and the results indicated an increased risk in males with a first malignancy of the salivary gland and in both men and women with a first thyroid malignancy. The salivary glands, larynx, and colon were the most common sites of second tumors after a first salivary cancer. The adrenals, brain, lymphatic system, and breast were the most common site after a first thyroid cancer. The previously reported association of cancers of the thyroid and the breast in females is confirmed here in men and women. The excess of brain tumors and lymphomas has not been reported previously.

Original languageEnglish (US)
Pages (from-to)718-721
Number of pages4
JournalLaryngoscope
Volume96
Issue number7
StatePublished - 1986

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Multiple Primary Neoplasms
Salivary Glands
Thyroid Gland
Neoplasms
Second Primary Neoplasms
Thyroid Neoplasms
Lymphatic System
National Cancer Institute (U.S.)
Skin Neoplasms
Larynx
Brain Neoplasms
Registries
Lymphoma
Colon
Breast

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Johns, M. E., Shikhani, A. H., Kashima, H. K., & Matanoski, G. (1986). Multiple primary neoplasms in patients with salivary gland or thyroid gland tumors. Laryngoscope, 96(7), 718-721.

Multiple primary neoplasms in patients with salivary gland or thyroid gland tumors. / Johns, Michael E.; Shikhani, Alain H.; Kashima, Haskins K.; Matanoski, Genevieve.

In: Laryngoscope, Vol. 96, No. 7, 1986, p. 718-721.

Research output: Contribution to journalArticle

Johns, ME, Shikhani, AH, Kashima, HK & Matanoski, G 1986, 'Multiple primary neoplasms in patients with salivary gland or thyroid gland tumors', Laryngoscope, vol. 96, no. 7, pp. 718-721.
Johns, Michael E. ; Shikhani, Alain H. ; Kashima, Haskins K. ; Matanoski, Genevieve. / Multiple primary neoplasms in patients with salivary gland or thyroid gland tumors. In: Laryngoscope. 1986 ; Vol. 96, No. 7. pp. 718-721.
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