Abstract
Multiple primary (MP) malignancies were found in 9.7% of 1961 patients with primary head and neck cancer diagnosed at The Johns Hopkins Hospital, Baltimore, during the years 1975 to 1985. The index tumors were divided into six main groups. Out of the 190 MP malignancies, 46.9% were synchronous and 53.1% were metachronous. Seventy-four percent of MP lesions were noted during the first year after diagnosis of the index primary tumor. Patients with an index tumor in the upper aerodigestive tract had a significantly increased risk of developing a second cancer in the head and neck area. This risk was 5.94 for the oral cavity, 6.98 for the pharynx, 3.57 for the larynx, and 7.02 for the esophagus. Patients with an index tumor in the salivary gland or the thyroid gland had, respectively, a 3.59 and a 7.38 higher risk than the general population of developing a second tumor. Efforts aimed at improving the survival of patients with head and neck cancer must incorporate strategies for the prevention, early detection, and treatment of MP neoplasms. (Arch Otolaryngol Head Neck Surg 1986;112:1172-1179)
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1172-1179 |
| Number of pages | 8 |
| Journal | Archives of Otolaryngology--Head and Neck Surgery |
| Volume | 112 |
| Issue number | 11 |
| DOIs | |
| State | Published - 1986 |
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ASJC Scopus subject areas
- Otorhinolaryngology
- Surgery
Cite this
Multiple Primary Malignancies in Head and Neck Cancer. / Shikhani, Alain H.; Matanoski, Genevieve; Jones, Mark M.; Kashima, Haskins K.; Johns, Michael E.
In: Archives of Otolaryngology--Head and Neck Surgery, Vol. 112, No. 11, 1986, p. 1172-1179.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multiple Primary Malignancies in Head and Neck Cancer
AU - Shikhani, Alain H.
AU - Matanoski, Genevieve
AU - Jones, Mark M.
AU - Kashima, Haskins K.
AU - Johns, Michael E.
PY - 1986
Y1 - 1986
N2 - Multiple primary (MP) malignancies were found in 9.7% of 1961 patients with primary head and neck cancer diagnosed at The Johns Hopkins Hospital, Baltimore, during the years 1975 to 1985. The index tumors were divided into six main groups. Out of the 190 MP malignancies, 46.9% were synchronous and 53.1% were metachronous. Seventy-four percent of MP lesions were noted during the first year after diagnosis of the index primary tumor. Patients with an index tumor in the upper aerodigestive tract had a significantly increased risk of developing a second cancer in the head and neck area. This risk was 5.94 for the oral cavity, 6.98 for the pharynx, 3.57 for the larynx, and 7.02 for the esophagus. Patients with an index tumor in the salivary gland or the thyroid gland had, respectively, a 3.59 and a 7.38 higher risk than the general population of developing a second tumor. Efforts aimed at improving the survival of patients with head and neck cancer must incorporate strategies for the prevention, early detection, and treatment of MP neoplasms. (Arch Otolaryngol Head Neck Surg 1986;112:1172-1179)
AB - Multiple primary (MP) malignancies were found in 9.7% of 1961 patients with primary head and neck cancer diagnosed at The Johns Hopkins Hospital, Baltimore, during the years 1975 to 1985. The index tumors were divided into six main groups. Out of the 190 MP malignancies, 46.9% were synchronous and 53.1% were metachronous. Seventy-four percent of MP lesions were noted during the first year after diagnosis of the index primary tumor. Patients with an index tumor in the upper aerodigestive tract had a significantly increased risk of developing a second cancer in the head and neck area. This risk was 5.94 for the oral cavity, 6.98 for the pharynx, 3.57 for the larynx, and 7.02 for the esophagus. Patients with an index tumor in the salivary gland or the thyroid gland had, respectively, a 3.59 and a 7.38 higher risk than the general population of developing a second tumor. Efforts aimed at improving the survival of patients with head and neck cancer must incorporate strategies for the prevention, early detection, and treatment of MP neoplasms. (Arch Otolaryngol Head Neck Surg 1986;112:1172-1179)
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UR - http://www.scopus.com/inward/citedby.url?scp=0022967159&partnerID=8YFLogxK
U2 - 10.1001/archotol.1986.03780110048006
DO - 10.1001/archotol.1986.03780110048006
M3 - Article
C2 - 3755993
AN - SCOPUS:0022967159
VL - 112
SP - 1172
EP - 1179
JO - Archives of Otolaryngology
JF - Archives of Otolaryngology
SN - 2168-6181
IS - 11
ER -