TY - JOUR
T1 - Multiple myeloma cancer stem cells
AU - Huff, Carol Ann
AU - Matsui, William
PY - 2008
Y1 - 2008
N2 - Multiple myeloma is characterized by the clonal expansion of neoplastic plasma cells within the bone marrow, elevated serum immunoglobulin, and osteolytic bone disease. The disease is highly responsive to a wide variety of anticancer treatments including conventional cytotoxic chemotherapy, corticosteroids, radiation therapy, and a growing number of agents with novel mechanisms of action. However, few if any patients are cured with these modalities and relapse remains a critical issue. A better understanding of clonogenic multiple myleoma cells is essential to ultimately improving long-term outcomes, but the nature of the cells responsible for myeloma regrowth and disease relapse is unclear. We review evidence that functional heterogeneity exists in multiple myeloma and discuss potential strategies and clinical implications of the stem-cell model of cancer in this disease.
AB - Multiple myeloma is characterized by the clonal expansion of neoplastic plasma cells within the bone marrow, elevated serum immunoglobulin, and osteolytic bone disease. The disease is highly responsive to a wide variety of anticancer treatments including conventional cytotoxic chemotherapy, corticosteroids, radiation therapy, and a growing number of agents with novel mechanisms of action. However, few if any patients are cured with these modalities and relapse remains a critical issue. A better understanding of clonogenic multiple myleoma cells is essential to ultimately improving long-term outcomes, but the nature of the cells responsible for myeloma regrowth and disease relapse is unclear. We review evidence that functional heterogeneity exists in multiple myeloma and discuss potential strategies and clinical implications of the stem-cell model of cancer in this disease.
UR - http://www.scopus.com/inward/record.url?scp=45549101709&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=45549101709&partnerID=8YFLogxK
U2 - 10.1200/JCO.2007.15.8428
DO - 10.1200/JCO.2007.15.8428
M3 - Review article
C2 - 18539970
AN - SCOPUS:45549101709
SN - 0732-183X
VL - 26
SP - 2895
EP - 2900
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 17
ER -