Multiple lineages of tumors express a common tumor antigen, P1A, but they are not cross-protected

L. Ramarathinam, S. Sarma, M. Maric, M. Zhao, G. Yang, L. Chen, Y. Liu

Research output: Contribution to journalArticle

Abstract

Whether tumors of different lineages share common Ags is a critical issue for understanding anti-tumor immune responses and for designing Ag-specific tumor immunotherapy. Because of lack of cross-protection among individually derived tumors, it has been proposed that tumor Ags are specific for individual tumors. Here we show that lack of cross-protection is not due to lack of a shared tumor Ag. Thus, a plasmocytoma J558 transfected with the costimulatory molecule B7 activates a cross-reactive CTL response in vivo. The major Ag recognized by the cross-reactive CTL is P1A, which is expressed in mastocytoma P815, plasmocytoma J558, and fibrosarcoma Meth A. Surprisingly, no significant cross-protection can be detected among P1A- expressing tumors after immunization with either P1A-expressing or B7- transfected P815 cells. Our results demonstrate that multiple lineages of tumors are not cross-protected even though they share a tumor Ag that can be recognized by CTL. These results have important implications for tumor immunotherapy.

Original languageEnglish (US)
Pages (from-to)5323-5329
Number of pages7
JournalJournal of Immunology
Volume155
Issue number11
StatePublished - 1995
Externally publishedYes

Fingerprint

Neoplasm Antigens
Neoplasms
Cross Protection
Plasmacytoma
Immunotherapy
B7 Antigens
Mastocytoma
Fibrosarcoma
Immunization

ASJC Scopus subject areas

  • Immunology

Cite this

Ramarathinam, L., Sarma, S., Maric, M., Zhao, M., Yang, G., Chen, L., & Liu, Y. (1995). Multiple lineages of tumors express a common tumor antigen, P1A, but they are not cross-protected. Journal of Immunology, 155(11), 5323-5329.

Multiple lineages of tumors express a common tumor antigen, P1A, but they are not cross-protected. / Ramarathinam, L.; Sarma, S.; Maric, M.; Zhao, M.; Yang, G.; Chen, L.; Liu, Y.

In: Journal of Immunology, Vol. 155, No. 11, 1995, p. 5323-5329.

Research output: Contribution to journalArticle

Ramarathinam, L, Sarma, S, Maric, M, Zhao, M, Yang, G, Chen, L & Liu, Y 1995, 'Multiple lineages of tumors express a common tumor antigen, P1A, but they are not cross-protected', Journal of Immunology, vol. 155, no. 11, pp. 5323-5329.
Ramarathinam L, Sarma S, Maric M, Zhao M, Yang G, Chen L et al. Multiple lineages of tumors express a common tumor antigen, P1A, but they are not cross-protected. Journal of Immunology. 1995;155(11):5323-5329.
Ramarathinam, L. ; Sarma, S. ; Maric, M. ; Zhao, M. ; Yang, G. ; Chen, L. ; Liu, Y. / Multiple lineages of tumors express a common tumor antigen, P1A, but they are not cross-protected. In: Journal of Immunology. 1995 ; Vol. 155, No. 11. pp. 5323-5329.
@article{533d116143894a1693455ef4053bacef,
title = "Multiple lineages of tumors express a common tumor antigen, P1A, but they are not cross-protected",
abstract = "Whether tumors of different lineages share common Ags is a critical issue for understanding anti-tumor immune responses and for designing Ag-specific tumor immunotherapy. Because of lack of cross-protection among individually derived tumors, it has been proposed that tumor Ags are specific for individual tumors. Here we show that lack of cross-protection is not due to lack of a shared tumor Ag. Thus, a plasmocytoma J558 transfected with the costimulatory molecule B7 activates a cross-reactive CTL response in vivo. The major Ag recognized by the cross-reactive CTL is P1A, which is expressed in mastocytoma P815, plasmocytoma J558, and fibrosarcoma Meth A. Surprisingly, no significant cross-protection can be detected among P1A- expressing tumors after immunization with either P1A-expressing or B7- transfected P815 cells. Our results demonstrate that multiple lineages of tumors are not cross-protected even though they share a tumor Ag that can be recognized by CTL. These results have important implications for tumor immunotherapy.",
author = "L. Ramarathinam and S. Sarma and M. Maric and M. Zhao and G. Yang and L. Chen and Y. Liu",
year = "1995",
language = "English (US)",
volume = "155",
pages = "5323--5329",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "11",

}

TY - JOUR

T1 - Multiple lineages of tumors express a common tumor antigen, P1A, but they are not cross-protected

AU - Ramarathinam, L.

AU - Sarma, S.

AU - Maric, M.

AU - Zhao, M.

AU - Yang, G.

AU - Chen, L.

AU - Liu, Y.

PY - 1995

Y1 - 1995

N2 - Whether tumors of different lineages share common Ags is a critical issue for understanding anti-tumor immune responses and for designing Ag-specific tumor immunotherapy. Because of lack of cross-protection among individually derived tumors, it has been proposed that tumor Ags are specific for individual tumors. Here we show that lack of cross-protection is not due to lack of a shared tumor Ag. Thus, a plasmocytoma J558 transfected with the costimulatory molecule B7 activates a cross-reactive CTL response in vivo. The major Ag recognized by the cross-reactive CTL is P1A, which is expressed in mastocytoma P815, plasmocytoma J558, and fibrosarcoma Meth A. Surprisingly, no significant cross-protection can be detected among P1A- expressing tumors after immunization with either P1A-expressing or B7- transfected P815 cells. Our results demonstrate that multiple lineages of tumors are not cross-protected even though they share a tumor Ag that can be recognized by CTL. These results have important implications for tumor immunotherapy.

AB - Whether tumors of different lineages share common Ags is a critical issue for understanding anti-tumor immune responses and for designing Ag-specific tumor immunotherapy. Because of lack of cross-protection among individually derived tumors, it has been proposed that tumor Ags are specific for individual tumors. Here we show that lack of cross-protection is not due to lack of a shared tumor Ag. Thus, a plasmocytoma J558 transfected with the costimulatory molecule B7 activates a cross-reactive CTL response in vivo. The major Ag recognized by the cross-reactive CTL is P1A, which is expressed in mastocytoma P815, plasmocytoma J558, and fibrosarcoma Meth A. Surprisingly, no significant cross-protection can be detected among P1A- expressing tumors after immunization with either P1A-expressing or B7- transfected P815 cells. Our results demonstrate that multiple lineages of tumors are not cross-protected even though they share a tumor Ag that can be recognized by CTL. These results have important implications for tumor immunotherapy.

UR - http://www.scopus.com/inward/record.url?scp=0028859570&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028859570&partnerID=8YFLogxK

M3 - Article

C2 - 7594546

AN - SCOPUS:0028859570

VL - 155

SP - 5323

EP - 5329

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 11

ER -