Multiple lineages of tumors express a common tumor antigen, P1A, but they are not cross-protected

L. Ramarathinam, S. Sarma, M. Maric, M. Zhao, G. Yang, L. Chen, Y. Liu

Research output: Contribution to journalArticle

Abstract

Whether tumors of different lineages share common Ags is a critical issue for understanding anti-tumor immune responses and for designing Ag-specific tumor immunotherapy. Because of lack of cross-protection among individually derived tumors, it has been proposed that tumor Ags are specific for individual tumors. Here we show that lack of cross-protection is not due to lack of a shared tumor Ag. Thus, a plasmocytoma J558 transfected with the costimulatory molecule B7 activates a cross-reactive CTL response in vivo. The major Ag recognized by the cross-reactive CTL is P1A, which is expressed in mastocytoma P815, plasmocytoma J558, and fibrosarcoma Meth A. Surprisingly, no significant cross-protection can be detected among P1A- expressing tumors after immunization with either P1A-expressing or B7- transfected P815 cells. Our results demonstrate that multiple lineages of tumors are not cross-protected even though they share a tumor Ag that can be recognized by CTL. These results have important implications for tumor immunotherapy.

Original languageEnglish (US)
Pages (from-to)5323-5329
Number of pages7
JournalJournal of Immunology
Volume155
Issue number11
Publication statusPublished - 1995
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Immunology

Cite this

Ramarathinam, L., Sarma, S., Maric, M., Zhao, M., Yang, G., Chen, L., & Liu, Y. (1995). Multiple lineages of tumors express a common tumor antigen, P1A, but they are not cross-protected. Journal of Immunology, 155(11), 5323-5329.