Multiple Hematopoietic-Cell Lineages in Multiple Myeloma

Ofer Shpilberg, Michaela Modan, Baruch Modan, Bracha Ramot, Joshua Epstein, Huiqing Xiao, Xiao Yan he

Research output: Contribution to journalLetter

Abstract

To the Editor: Using flow cytometry, Epstein and colleagues (March 8 issue)* found that myeloma cells expressed not only features characteristic of myeloma cells but also markers expressed on preB cells, megakaryocytes, myelomonocytes, and erythroid cells. The authors concluded that cells of multiple lineages are involved in multiple myeloma, and mentioned that these findings could imply the existence of a common neoplastic progenitor for all hematologic tumors. Another way to investigate the level at which the malignant process occurs in hematologic cancers is by determining the familial aggregation of hematologic cancers among patients with a specific disease — i.e., multiple…

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Volume323
Issue number4
DOIs
StatePublished - Jul 26 1990
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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